McMaster Update in Thromboembolism

The McMaster University Continuing Professional Development Office is pleased to present the virtual Seventeenth Annual McMaster Update in Thromboembolism, Friday, October 1, 2021. Thank you to Elaine Benoit, Precision BioLogic, for the heads-up.

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Thrombophilia

Aug 31 2021

george

Webinar: Rare Thrombotic Response to a SARS-CoV-2 Vaccine

Please join us for a compelling discussion about the rare, unusual thrombotic events that develop in association with thrombocytopenia approximately one to two weeks after vaccination with a SARS-CoV-2 vaccine. This incidence of thrombocytopenia is mediated by platelet-activating antibodies against platelet-factor 4, without any exposure to heparin, and it mimics heparin-induced thrombocytopenia. Don’t miss this […]

Events

Thrombosis in VWF and Hemophilia

From Crystal Wilson: Hello George, I am writing to ask if you could help me to understand how, on rare occasions, patients suffering from bleeding disorders such as von Willebrand disease or hemophilia have suffered from hypercoagulable episodes such as pulmonary emboli or deep vein thrombosis. Thanks. Hello, Crystal, I sent your question to several […]

Bleeding Disorders

July, 2021 Quick Question: Covid Inflammatory Cell Results

Our July, 2021 Quick Question was, “Which cell is the main cause of thrombo-inflammation in a COVID-19 infection?” We had 43 respondents to our selections: Endothelial cell: 35% [15] Platelet: 44% [19] Monocyte-macrophage: 12% [5] polymorphonuclear neutrophil: 9% [4] There’s no right answer, as all of these cells are involved in inflammation, however, many who […]

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Quick Question Archive

Jul 11 2021

george

VITT Mechanism Nature Preview

Here is a research article that was rushed to print in the July 7, 2021 Nature that describes the precise pathophysiology of vaccine-induced immune thrombotic thrombocytopenia [VITT]. VITT is the critical 1/60,000 incidence adverse event associated with the adenoviral vector employed in the Astra-Zeneca and Johnson and Johnson vaccines, among others. VITT resembles heparin-induced thrombocytopenia […]

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Platelet Function Testing

Jun 29 2021

george

July, 2021 Quick Question: Covid Inflammatory Cell

On June 30, 2021, I [Geo] presented “Covid-coag Controversies, What is Immuno-Thrombo-Inflammation” at the Joint Annual Meeting of the American Society for Clinical Laboratory Science, the Association of Genetic Technologists, and the Society of Armed Forces Medical Laboratory Scientists in Louisville, Kentucky. My handout for the meeting is attached. In follow-up, our July Quick Question […]

Thrombophilia

New Fundamentals in Hemostasis

Thanks to my colleague Carlo Ledesma, MS, SH(ASCP)QLS, MT(ASCPi), MT(AMT) for pointing me to an in-depth hemostasis review, Versteeg HH, Heemskerk JWM, Levi M, Reitsma PH. New Fundamentals in Hemostasis. Physiol Rev 2013;93:327–58. This is a valuable teaching resource that helps elucidate the cell-based hemostasis model.

Arterial Thrombosis

Mixing Study Limits

From a participant: Can you please help me to understand how to make a cut off value for a correction study so that above this value is corrected and below is not? Please provide an example. Thank you. Hello, and thank you for your question. Please click this link to our educational module, “Improving Acute […]

Bleeding Disorders

bigEndothelin-1

Here is a significant study of a plasma component associated with thrombosis in immune thrombotic thrombocytopenic purpura published by a colleague and friend, Dr. X Long Zheng, an iTTP expert, and his associate, Dr. Nancy Lu: Lu R, Zheng XL. Plasma levels of bigEndothelin-1 are associated with renal insufficiency and in-hospital mortality of immune thrombotic […]

Thrombophilia

Covid Coag: Thromboinflammation Talk

On Thursday, April 29, 7–8 CDT, George presents for the American Society for Clinical Laboratory Science–North Dakota via Zoom, “COVID-Coag: What the Heck is “Immuno-thrombo-inflammation?” Here is the updated six-per-page handout for my presentation.

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Thrombophilia

Thrombophilia

McMaster Update in Thromboembolism

Webinar: Rare Thrombotic Response to a SARS-CoV-2 Vaccine

Thrombosis in VWF and Hemophilia

July, 2021 Quick Question: Covid Inflammatory Cell Results

VITT Mechanism Nature Preview

July, 2021 Quick Question: Covid Inflammatory Cell

New Fundamentals in Hemostasis

Mixing Study Limits

bigEndothelin-1

Covid Coag: Thromboinflammation Talk

George Fritsma MS MLS

Cheat Sheets from George

Questions or Comments?

Quick Question