Field Study Compares OSA With CSA for Measuring Efanesoctocog Alfa

Here is an open-access article contrasting the validity of OSA versus CSA for measuring efanesoctocog alfa (Altuviiio®) spiked into normal plasma: Pipe S, Sadeghi-Khomami A, Konkle BA, et al. A global comparative field study to evaluate the factor VIII activity of efanesoctocog alfa by one-stage clotting and chromogenic substrate assays at clinical haemostasis laboratories. Haemophilia. […]

Comments (0)

Factor Assays

Dec 26 2025

george

August 2025 CAP Today: D-dimer Reporting and INR Are Variables That Matter

In follow-up to their July 2025 CAP Today article, A Deep Dive into Key Hemostasis Testing Variables, Drs. Andrew Goodwin and Eric Salazar present external quality improvement data on the PT–INR, D-dimer, and VET in their August 2025 article, D-dimer Reporting and INR Are Variables That Matter. Their article in particular examines the confusion over […]

Comments (0)

Anticoagulant Therapy

Dec 18 2025

george

AI in Thrombosis and Hemostasis

Here is an open-access article on the efficacy of artificial intelligence in hemostasis: Altememi MA, Favaloro EJ, Islam MZ, Santhakumar AB. Artificial intelligence and machine learning in thrombosis and hemostasis: a scoping review of clinical and laboratory applications, challenges, and future directions. Clin Chem Lab Med. 2025. doi: 10.1515/cclm-2025-1450. PMID: 41400592. Abstract This scoping review […]

Validation

Let’s Update Hemostasis Test Names

Here is a provocative recommendation from colleague and friend, Dan Kaczor: Hi George, This is the follow-up on the issue of nomenclature posted on 12-1-2025. Although there may be reasons to consider change, as pointed out in the examples given, I believe that we are moving in the wrong direction and are making things difficult […]

Validation

October 2025 QQ: Reporting Assay Uncertainty Data Summary

Our October 2025 Quick Question was a poll that asked, “Do you support publishing assay uncertainty data with all results?” The poll attracted 13 respondents who answered: Yes: 4 (31%) No: 8 (62%) It depends: 1 (7%) While the response was small, our question attracted several vigorous comments (click). Generalizing, this hourglass figure, cited in Stroobants […]

Comments (0)

Quick Question Archive

Sep 29 2025

george

October 2025 QQ: Reporting Assay Uncertainty Data

Please refer to our August 29, 2025 discussion, “Hemostasis Assay Statistical Variation.” In this post, we linked the article, Mullier F, Gouin-Thibault I, Meijer P, et al. Time to integrate measurement uncertainty in method comparison and interpretation of hemostasis laboratory assays. Res Practice Thromb Hemost 2025: 9, https://doi.org/10.1016/j.rpth.2025.102993. The authors contend that we should report uncertainty […]

Comments (7)

Quick Question Archive

Sep 10 2025

george

Poster: Monitoring FVIII in Hemophilia Patients Treated with Bypassing Therapeutics

To review the PBI poster presented at the 2025 ISTH meeting, click Effect of Mim8 and Emicizumab on Factor VIII Recovery by a Novel, Bovine Chromogenic FVIII Assay. Tara Quinton, Meghan Bruhm, Karen M. Black, Ali Sadeghi-Khomami. Precision BioLogic Inc., Dartmouth, Nova Scotia, Canada. The poster illustrates the validity of bovine reagent-based chromogenic substrate FVIII […]

Bleeding Disorders

Quality Management in a Hemostasis Laboratory

Here’s an open-access August 2025 article, Sarkar MK, Quality management in a hemostasis laboratory. This article is an excellent companion to our August 29, 2025 post, Hemostasis Assay Statistical Variability. The August post referenced my colleague and friend, Dr. Mayukh Sarkar, who narrated our Hemostasis Quality Control units that are linked in the August post […]

Validation

Hemostasis Assay Statistical Variability

Here is an open-access commentary that addresses concerns about hemostasis assay statistical variability as it relates to clinical significance. Click: Mullier F, Gouin-Thibault I, Meijer P, et al. Time to integrate measurement uncertainty in method comparison and interpretation of hemostasis laboratory assays. Res Practice Thromb Hemost 2025: 9, https://doi.org/10.1016/j.rpth.2025.102993. For a two-part discussion about hemostasis quality assurance […]

Validation

Indirect Reference Interval Determination

Sarkar MK, Fritsma GA, Chapter 3, Quality Assurance in Hematology Testing; Keohane EM, Butina MM, Mirza KM, Walenga JM. Rodak’s Hematology: Clinical Principles and Applications Edition 7 states the following: “Indirect RIs may be derived from stored patient data. The QC specialist mines the laboratory database to compute the mean and confidence interval. Indirect RI […]

Comments (2)

Validation

Validation

Field Study Compares OSA With CSA for Measuring Efanesoctocog Alfa

August 2025 CAP Today: D-dimer Reporting and INR Are Variables That Matter

AI in Thrombosis and Hemostasis

Let’s Update Hemostasis Test Names

October 2025 QQ: Reporting Assay Uncertainty Data Summary

October 2025 QQ: Reporting Assay Uncertainty Data

Poster: Monitoring FVIII in Hemophilia Patients Treated with Bypassing Therapeutics

Quality Management in a Hemostasis Laboratory

Hemostasis Assay Statistical Variability

Indirect Reference Interval Determination

George Fritsma MS MLS

Cheat Sheets from George

Questions or Comments?

Quick Question