Bleeding Disorders

February, 2023 Quick Question: VWF Activity Assays

Our February 2023 Quick Question, “What VWF activity assay do you use?” attracted 32 responses. Here are the results: Automated VWF:RCo: 12 [38%] VWF:RCo: 10 [31%] VWF:GP1bR: 3 [9%] VWF:GP 1bM: 4 [13%] VWF:Ab: 2 [6%] VWF:CB: 1 [3%] Although the aggregometer-based ristocetin cofactor activity assay [VWF:RCo] is criticized for poor reproducibility, with interassay CV […]

Bleeding Disorders

January, 2023 Quick Question: Tranexamic Acid

Our January 2023 Quick Question asks, What is the target of the anti-hemorrhagic agent tranexamic acid? For this question, the only correct answer is fibrinolysis. Here are the responses from our 57 participants… Factor V: 5 [9%] Factor XIII: 5 [9%] Fibrinolysis: 40 [70%] Prothrombin 4 [7%] Activated protein C 3 [5%] This QQ is […]

Quick Question Archive

VWF Activity Assay

Preliminary to our February 2023 Quick Question, here is a detailed January 2023 CAP Today article entitled “Ins and Outs of von Willebrand Factor Activity Assays.” In addition to the time-honored, but imprecise optical aggregometry-based von Willebrand Ristocetin Cofactor [VWF:RCo] assay, we now have these activity assays that, except for VWF:RCo, function without reagent-platelets… VWF:RCo: […]

Bleeding Disorders

Prehospital Transfusion

Here is a provocative article from the December 2022 issue of CAP Today that addresses the benefits and barriers to offering pre-hospital transfusions in trauma situations: Prehospital Transfusions, CAP Today, December 2022.

Bleeding Disorders

Precision BioLogic Chromogenic FIX Assay Cleared by the FDA

Congratulations to our sponsor, Precision BioLogic Inc., as their CRYOcheck chromogenic factor IX assay was cleared by the US Food and Drug Administration on January 5, 2023. Click here for PBI’s news release. and click “Factor IX Testing and Introduction to CRYOcheck Chromogenic Factor IX” to register for our February 1 webinar featuring special guest […]

Coagulation Factors

January 2023 Quick Question: Tranexamic Acid

On October 25, 2022, I [Geo] had total knee replacement surgery. Just before becoming unconscious, I asked the anesthesiologist what was in the IV. I was surprised to learn one of my therapeutics was tranexamic acid [TXA], whose purpose was to control bleeding. TXA has been around for a long time, but I’m curious about […]

Quick Question Archive

Non-severe Hemophilia Treatment

Here is a meta-analysis of concentrate treatment for mild to moderate hemophilia. Iorio A, Königs C, Reding MT, et al. Prophylaxis use of clotting factor replacement products in people with non-severe haemophilia: A review of the literature. Haemophilia. 2022. doi: 10.1111/hae.14676.

Bleeding Disorders

FDA Approves Gene Therapy for Hemophilia B

Click here for CSL Behring’s press release from November 22, 2022, announcing FDA approval of etranacogene dezaparvovec [Hemgenix] for adult Hemophilia B [factor IX deficient] patients.

Bleeding Disorders

Chromogenic Factor IX Assay Validation

Click below for a poster that was presented at the Thrombosis and Hemostasis Summit of North America [THSNA], August 16–18, 2022 that features a recently released chromogenic factor IX assay: Quinton T, Fraser J, Black KM, Sadeghi-Khomami A. Validation of a new kit for the determination of factor IX activity, Poster 418, Precision BioLogic Inc., […]

Bleeding Disorders

July 2022 QQ: Reduced concentration RIPA test.responses

Our July 2022 Quick Question asked, “What VWD subtype is identified using the reduced concentration RIPA test?” We received 30 votes. Here are our answers: VWD Type 1: 10% [3] VWD Type 1C: 0 VWD Subtype 2A: 3% VWD Subtype 2B: 87% VWD Subtype 2M: 0 VWD Subtype 2N: 0 VWD Type 3: 0 Few […]

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

Cheat Sheets from George

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