Bleeding Disorders

July 2026 QQ Summary: VWD Therapeutic

Our July 2026 QQ asked: What VWD therapeutic is NOT a replacement factor? Our 24 participants responded… Desmopressin: 18 (75%) Humate P: 1 (4%) Vonvendi: 4 (17%) Wilate: 1 (4%) VWD bleeding is first managed by applying “PRICE:” protection, rest, ice, compression, and elevation. Next, desmopressin (DDAVP) is administered via injection, infusion, and, in Europe, […]

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Emicizumab Therapy for the Newborn

Click for this Hemostasis Today column, Abdul Mannan: HAVEN 7 and the Future of Early Haemophilia Care. For a detailed follow-up to the HAVEN 7 trial, check your medical library for de Kovel M, Kenet G, Motwani J, et al; PedNet Study group. FVIII exposure, bleeding outcomes, and inhibitor development in 80 PUPs and MTPs […]

Bleeding Disorders

Why Does Blood Group O Reduce VWF?

Dr. Abdul Mannan’s LinkedIn post, “Why Does Blood Group O Reduce VWF?” presents the physiology of VWF in blood group O.

Bleeding Disorders

Why Clotting Patients Bleed

Abdul Mannan, Consultant Haematologist at Betsi Cadwaladr University Health Board, shared a column, Why Clotting Patients Bleed, in Hemostasis Today.

July 2026 QQ: VWD Therapeutic

We commemorate the 1926 publication by Finnish physician, Eric von Willebrand, Von Willebrand, E A (1926). “Hereditär pseudohemofili”. Finska Läkaresällskapets Handlingar (in Swedish). 68: 87–112. Dr. von Willebrand’s title, “Hereditary Pseudohemophilia,” was updated to our current name, von Willebrand disease, in the late 1930s, and the responsible protein was named von Willebrand factor in 1971. […]

Bleeding Disorders

June 2026 QQ Review: VWF Gain of Function

Our June 2026 QQ, which drew 30 responses, asked, “What VWD subtype is caused by a VWF gain of function?” Here are your responses: VWD type 1: 3 (10%) VWD subtype 2A: 1 (3%) VWD subtype 2B: 24 (80%) VWD subtype 2M: 2 (7%) VWD subtype 2N: 0 VWD type 1 is the quantitative form […]

Bleeding Disorders

A New Era in VWD Treatment

Click here for an informative LinkedIn/Hemostasis Today post from Shadi Tabibian, Deputy of Research at Blood Diseases Research Centers in Iran University of Medical Sciences, A New Era in VWD Treatment. For decades, the management of VWD has relied mainly on VWF concentrates, desmopressin, antifibrinolytic agents, and hormonal therapies. Although these treatments remain effective for […]

Bleeding Disorders

Review: Diagnosis and Management of Hemophilia A & B

Click here for an open-access review: Lim MY, Ardila J, Castaman G, et al. Diagnosis and management of hemophilia A and B. J Thromb Haemost. 2026;24:2341–54. doi: 10.1016/j.jtha.2026.04.005. PMID: 41967712. Abstract Hemophilia A and hemophilia B are inherited bleeding disorders caused by a deficiency or absence of coagulation factor FVIII and FIX, respectively. The severity […]

Bleeding Disorders

Coag Conversation: 100 Years of Von Willebrand Disease and Upcoming Advances

Click here for the first of our three-part Coag Conversation series, 100 Years of von Willebrand disease. featuring George Fritsma interviewing Robert Sidonio, MD. Dr. Sidonio is the Medical Director of the Clinical Research Office at the Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta and is the Professor of Pediatrics, Emory […]

Bleeding Disorders

Emergency Hemorrhage Hemostasis Profile

Cristina Figueroa Villalba, MD, authored a provocative editorial, When minutes matter: the laboratory’s role in rapid hemostasis assessment in the May/June issue of CLN, a publication of ADLM. Please review this 10-minute read and respond with your recommendations for a rapid-test profile for acute hemorrhage. For instance, would you include a PTT, the DOASENSE® urinary […]

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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