Bleeding Disorders

Review: Diagnosis and Management of Hemophilia A & B

Click here for an open-access review: Lim MY, Ardila J, Castaman G, et al. Diagnosis and management of hemophilia A and B. J Thromb Haemost. 2026;24:2341–54. doi: 10.1016/j.jtha.2026.04.005. PMID: 41967712. Abstract Hemophilia A and hemophilia B are inherited bleeding disorders caused by a deficiency or absence of coagulation factor FVIII and FIX, respectively. The severity […]

Bleeding Disorders

Coag Conversation: 100 Years of Von Willebrand Disease and Upcoming Advances

Click here for the first of our three-part Coag Conversation series, 100 Years of von Willebrand disease. featuring George Fritsma interviewing Robert Sidonio, MD. Dr. Sidonio is the Medical Director of the Clinical Research Office at the Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta and is the Professor of Pediatrics, Emory […]

Bleeding Disorders

Emergency Hemorrhage Hemostasis Profile

Cristina Figueroa Villalba, MD, authored a provocative editorial, When minutes matter: the laboratory’s role in rapid hemostasis assessment in the May/June issue of CLN, a publication of ADLM. Please review this 10-minute read and respond with your recommendations for a rapid-test profile for acute hemorrhage. For instance, would you include a PTT, the DOASENSE® urinary […]

Bleeding Disorders

Factor XIII and Clot Stability

Click here for an open-access illustrated discussion via Hemostasis Today by Abdul Mannan of the multiple roles of FXIII and the adverse effects of FXIII deficiency related to wound healing and clot integrity.

June 2026 QQ: VWF Gain of Function

In keeping with our “100 Years of VWD” theme, our June 2026 Quick Question, which appears in the right-hand column, asks, “What VWD subtype is caused by a VWF gain of function?” Gain of function refers to VWF with enhanced binding avidity to the platelet GP1b binding site. For assistance, navigate to our Informative Module, […]

Quick Question Archive

“Covid Coag”

On May 26, I (Geo) posted a link to our informational module, The Cell-based Coagulation Model. On May 15, I posted a link to our Coagulation Overview Module. The third in a series of “Mechanism” modules, and perhaps the most complex, is entitled Covid Coag. Though thanks to vaccination technology, we think less today about […]

Bleeding Disorders

A Treasure Trove of VWD Articles

The May 2026 issue of Seminars in Thrombosis and Hemostasis provides a “mother lode” of open-access VWD articles in observance of Dr. Erik von Willebrand‘s 1926 article, Hereditar Pseudohaemophili, now 100 YOA. Check with your medical library for Nilsson IM. Commentary to Erik von Willebrand’s original paper in Haemophilia. 1999;5:220-1. doi: 10.1046/j.1365-2516.1999.0320a.x. PMID: 10444292 (no […]

Bleeding Disorders

Aspirin Prophylaxis

The question appeared on the Diagnostic Equity site, paraphrased with the approval of site proprietor Tamara Lobban-Jones: “I’ve heard that some people take a ‘ton of baby aspirin.’ My doc told me to take only one a day. Does taking multiple tablets help with clotting? What does taking one aspirin do to the blood, and […]

Antiplatelet Therapy

VWD Test Panel: A Correction

Thanks to Dr. Emmanuel Favaloro for pointing out an error in our April 29 post, “Quick Question Results, VWF Activity.” I (Geo) had transposed the principles of the VWF:GP1bR and VWF:GP1bM. I’ve corrected the error in the April 29 post–the correct principles are that VWF:GP1bR employs ristocetin, whereas VWF:GP1bM employs a gain-of-function form of GP1b […]

Bleeding Disorders

April 2026 QQ Results: VWF Activity

Our April 2026 Quick Question reprises our 2023 QQ that asked, How do you measure VWF activity. Our 29 respondents answered as follows: VWF:RCo: 16 (56%) VWF:GP1bR: 6 (21%) VWF:GP1bM: 5 (16%) VWF:CB: 2 (7%) RIPA: 0 Our 4-1-2026 introductory QQ post attracted this comment from Dr. Emmanual Favaloro, Sydney, NSW, Australia: Hi George, of course, […]

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

Cheat Sheets from George

Quick Question