Why Clotting Patients Bleed

Abdul Mannan, Consultant Haematologist at Betsi Cadwaladr University Health Board, shared a column, Why Clotting Patients Bleed, in Hemostasis Today.

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Thrombophilia

Jun 18 2026

george

What is CAPS?

Here is an illustrated Hemostasis Today description by Dr. Abdul Mannan, Consultant Haematologist at Betsi Cadwaladr University Health Board, of catastrophic antiphospholipid syndrome (CAPS), which accounts for 1% of antiphospholipid syndrome (APS) diagnoses. As Dr. Mannan reports, the APL assay is a vital diagnostic consideration of this acute condition.

Lupus Anticoagulant

VTE in Sickle Cell Disease

Click this open-access 2026 article for a retrospective review of individuals with sickle cell disease to identify those who developed VTE. Bhasin N, Zhang L, Ajayi A, et al. Risk factors for venous thromboembolism in sickle cell disease. Res Pract Thromb Haemost. 2026;10(3):103454. doi: 10.1016/j.rpth.2026.103454. PMID: 42027307; PMCID: PMC13099461. Abstract Background: Individuals with sickle cell […]

Thrombophilia

A 2026 Review of D-dimer Reporting Variations in VTE

Here is an open-access 2026 review that illustrates the reporting variations and application of the D-dimer assay in VTE. Hofstetter RV, Marx CE, Kraaijpoel N, Favaloro EJ, et al. Reporting of D-dimer testing in venous thromboembolism diagnostic management studies: a scoping review. J Thromb Haemost. 2026:S1538-7836(26)00190-X. doi: 10.1016/j.jtha.2026.03.005. PMID: 41839295. Abstract Background: D-dimer testing is […]

Thrombophilia

Perioperative Management of Antiphospholipid Syndrome Study

Click here for the open-access article, Paquette M, Miranda S, Xu Y, et al. Perioperative management of antithrombotic therapy in patients with thrombotic antiphospholipid syndrome. Blood Adv. 2026;10(9):3218–28. doi: 10.1182/bloodadvances.2026019610. PMID: 41843780; PMCID: PMC13136740. Abstract Patients with thrombotic antiphospholipid syndrome (APS) frequently require interruption of anticoagulation for invasive procedures; however, data to guide the perioperative […]

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Anticoagulant Therapy

Apr 8 2026

george

Iron Deficiency and Venous Thrombosis in Polycythemia Vera

Here is the abstract of a THSNA presentation, Thursday, 3-19-2026: Iron Deficiency Can Increase the Risk of Venous Thromboembolism in Hospitalized Patients with Polycythemia Vera: A Nationwide Analysis (THSNATravel Awardee) Kavya Balusu, Purva Shah, Candrika D. Khairani, Peter Kouides Rochester General Hospital, Rochester, NY, United States Background: Thrombosis is the leading cause of morbidity and […]

Thrombophilia

Plasminogen Deficiency and Ligneous Conjunctivitis

Dr. Amy Shapiro, Medical Director and CEO, Innovative Hematology & Indiana Hemophilia & Thrombosis Center, provided a THSNA “rare disorders presentation, Diagnosing plasminogen deficiency–clinical and laboratory considerations. Abstract: Type 1 plasminogen deficiency (PLGD) or hypoplasminogenemia is an ultrarare disorder caused by pathogenic variants in the PLG, resulting in decreased functional and antigenic plasminogen levels. PLGD […]

Thrombophilia

Review: Antiphospholipid Antibodies and Cardiovascular Thrombosis

Go to your medical library for this pre-print review: Rashedi S, Leyva H, Siddiqui SA, et al. Antiphospholipid antibodies and cardiovascular thrombosis. Nat Rev Cardiol. 2026. doi: 10.1038/s41569-026-01269-9. PMID: 41807758. Abstract Antiphospholipid antibodies (aPL) are directed against phospholipids and phospholipid-binding proteins. Laboratory assays used to detect aPL include serological tests for aPL against β2-glycoprotein 1, […]

Thrombophilia

Review: Acquired Hemostasis Disorders

See this open-access review on acquired hemostasis disorders: Tufano A, Franchini M, Coppola A. Acquired hemostasis disorders. Semin Thromb Hemost. 2026;52:277–9. doi: 10.1055/a-2788-1844. PMID: 41802449.

Bleeding Disorders

Research Report Examines Efficacy of Chemiluminescence HIT Assay

Here is an open-access article describing the efficacy of a chemiluminescence HIT assay: Bowyer A, Kohama K, Patel I, et al’A new, rapid, chemiluminescence enzyme assay for the detection of heparin-induced thrombocytopenia: a comparison between functional and immune heparin-induced thrombocytopenia assays, Res Prac in Thrombosis and Haemostasis,2026;10, 103373, ISSN 2475-0379, https://doi.org/10.1016/j.rpth.2026.103373. Abstract Background Heparin-induced thrombocytopenia […]

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Thrombophilia

Thrombophilia

Why Clotting Patients Bleed

What is CAPS?

VTE in Sickle Cell Disease

A 2026 Review of D-dimer Reporting Variations in VTE

Perioperative Management of Antiphospholipid Syndrome Study

Iron Deficiency and Venous Thrombosis in Polycythemia Vera

Plasminogen Deficiency and Ligneous Conjunctivitis

Review: Antiphospholipid Antibodies and Cardiovascular Thrombosis

Review: Acquired Hemostasis Disorders

Research Report Examines Efficacy of Chemiluminescence HIT Assay

George Fritsma MS MLS

Cheat Sheets from George

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