Risk of PE in Octogenarians

Here is a provocative open-access case-control article: Lipa AJ, Janata-Schwatczek K, Sterz M, et al. Too old for PESI?: risk stratification of octogenarians with pulmonary embolism in the emergency department. Semin Thromb Hemost. 2026. doi: 10.1055/a-2896-8297. PMID: 42361814. Abstract Pulmonary embolism (PE) in octogenarians (i.e., patients >80 years) is associated with substantial morbidity and mortality, yet […]

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Thrombophilia

Jul 13 2026

george

A LAC Assay that Resists DOAC Interference

Click Rahman M, Black KM, Sadeghi-Khomami A; An Automated Lupus Anticoagulant Assay Resistant to Anticoagulant Drugs Including DOACs and Oral FXI Inhibitors for a 2016 ISTH poster that documents an updated LAC assay. Background Direct oral anticoagulants (DOACs) and oral FXI inhibitors interfere with LAC testing by prolonging clotting times and increasing assay variability. Activated charcoal […]

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Anticoagulant Therapy

Jul 2 2026

george

Why Clotting Patients Bleed

Abdul Mannan, Consultant Haematologist at Betsi Cadwaladr University Health Board, shared a column, Why Clotting Patients Bleed, in Hemostasis Today.

Thrombophilia

What is CAPS?

Here is an illustrated Hemostasis Today description by Dr. Abdul Mannan, Consultant Haematologist at Betsi Cadwaladr University Health Board, of catastrophic antiphospholipid syndrome (CAPS), which accounts for 1% of antiphospholipid syndrome (APS) diagnoses. As Dr. Mannan reports, the APL assay is a vital diagnostic consideration of this acute condition.

Lupus Anticoagulant

VTE in Sickle Cell Disease

Click this open-access 2026 article for a retrospective review of individuals with sickle cell disease to identify those who developed VTE. Bhasin N, Zhang L, Ajayi A, et al. Risk factors for venous thromboembolism in sickle cell disease. Res Pract Thromb Haemost. 2026;10(3):103454. doi: 10.1016/j.rpth.2026.103454. PMID: 42027307; PMCID: PMC13099461. Abstract Background: Individuals with sickle cell […]

Thrombophilia

A 2026 Review of D-dimer Reporting Variations in VTE

Here is an open-access 2026 review that illustrates the reporting variations and application of the D-dimer assay in VTE. Hofstetter RV, Marx CE, Kraaijpoel N, Favaloro EJ, et al. Reporting of D-dimer testing in venous thromboembolism diagnostic management studies: a scoping review. J Thromb Haemost. 2026:S1538-7836(26)00190-X. doi: 10.1016/j.jtha.2026.03.005. PMID: 41839295. Abstract Background: D-dimer testing is […]

Thrombophilia

Perioperative Management of Antiphospholipid Syndrome Study

Click here for the open-access article, Paquette M, Miranda S, Xu Y, et al. Perioperative management of antithrombotic therapy in patients with thrombotic antiphospholipid syndrome. Blood Adv. 2026;10(9):3218–28. doi: 10.1182/bloodadvances.2026019610. PMID: 41843780; PMCID: PMC13136740. Abstract Patients with thrombotic antiphospholipid syndrome (APS) frequently require interruption of anticoagulation for invasive procedures; however, data to guide the perioperative […]

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Anticoagulant Therapy

Apr 8 2026

george

Iron Deficiency and Venous Thrombosis in Polycythemia Vera

Here is the abstract of a THSNA presentation, Thursday, 3-19-2026: Iron Deficiency Can Increase the Risk of Venous Thromboembolism in Hospitalized Patients with Polycythemia Vera: A Nationwide Analysis (THSNATravel Awardee) Kavya Balusu, Purva Shah, Candrika D. Khairani, Peter Kouides Rochester General Hospital, Rochester, NY, United States Background: Thrombosis is the leading cause of morbidity and […]

Thrombophilia

Plasminogen Deficiency and Ligneous Conjunctivitis

Dr. Amy Shapiro, Medical Director and CEO, Innovative Hematology & Indiana Hemophilia & Thrombosis Center, provided a THSNA “rare disorders presentation, Diagnosing plasminogen deficiency–clinical and laboratory considerations. Abstract: Type 1 plasminogen deficiency (PLGD) or hypoplasminogenemia is an ultrarare disorder caused by pathogenic variants in the PLG, resulting in decreased functional and antigenic plasminogen levels. PLGD […]

Thrombophilia

Review: Antiphospholipid Antibodies and Cardiovascular Thrombosis

Go to your medical library for this pre-print review: Rashedi S, Leyva H, Siddiqui SA, et al. Antiphospholipid antibodies and cardiovascular thrombosis. Nat Rev Cardiol. 2026. doi: 10.1038/s41569-026-01269-9. PMID: 41807758. Abstract Antiphospholipid antibodies (aPL) are directed against phospholipids and phospholipid-binding proteins. Laboratory assays used to detect aPL include serological tests for aPL against β2-glycoprotein 1, […]

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Thrombophilia

Thrombophilia

Risk of PE in Octogenarians

A LAC Assay that Resists DOAC Interference

Why Clotting Patients Bleed

What is CAPS?

VTE in Sickle Cell Disease

A 2026 Review of D-dimer Reporting Variations in VTE

Perioperative Management of Antiphospholipid Syndrome Study

Iron Deficiency and Venous Thrombosis in Polycythemia Vera

Plasminogen Deficiency and Ligneous Conjunctivitis

Review: Antiphospholipid Antibodies and Cardiovascular Thrombosis

George Fritsma MS MLS

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