Heparin Effect on Chemiluminescence HIT Testing

Check with your local library for this HIT testing report: Vong R, Pasalic L, Donikian D, Brighton T, Favaloro EJ. Effect of heparin on immunological heparin-induced thrombocytopenia-IgG chemiluminescence testing. Blood Coagul Fibrinolysis. 20261;37(7):329-335. doi: 10.1097/MBC.0000000000001456. PMID: 42615582. Heparin-induced thrombocytopenia (HIT) requires clinical evaluation and laboratory testing using immunological assays with confirmation by functional assays such […]

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Anticoagulant Therapy

Oct 1 2026

george

July 2026 CAP Today Q & A Column: Lipoprotein (a).

Q. Our providers pointed out that lipoprotein(a) results from different laboratories are discordant, so they asked us to bring the assay in-house. Is this a good idea? A. Lipoprotein(a), or Lp(a), is a prothrombotic, proinflammatory, and atherogenic cholesterol-rich particle. Plasma concentration of Lp(a) is an important genetic determinant of atherosclerotic cardiovascular disease (ASCVD) risk, and […]

Thrombophilia

September 2026 QQ Summary: Anticoagulant Therapy for LAC Patients with VTE

Our September 2026 QQ asked: In your facility, what AC do you use for LAC patients with VTE? Our 13 respondents answered: Anti-Xa DOAC: 5 (39%) Warfarin: 8 (61%) No one chose an anti-IIa DOAC, aspirin, or “none.” There have been provocative discussions among KOL experts comparing the long-term use of warfarin (VKA) v. anti-Xa […]

Thrombophilia

Review: Pediatric VTE

While we focus on arterial and venous thrombosis, October 13 is the official World Thrombosis Day. With this thought in mind, here is a richly illustrated review describing pediatric VTE: Espanol MG, Janbain M. Pediatric venous thromboembolism: an illustrated review. Res Pract Thromb Haemost. 2026;10:106892. doi: 10.1016/j.rpth.2026.106892. PMID: 42699084; PMCID: PMC13543900. Abstract Venous thromboembolism (VTE) […]

Thrombophilia

Can AI Replace Clinical Prediction Scores in Thrombophilia?

Here is an open-access that compares the efficacy of AI with traditional clinical prediction scores for thrombophilia: Danilatou V, Arachchillage DJ. Beyond accuracy: why replacing traditional scores with AI in thrombosis care creates new ethical and regulatory obligations. Semin Thromb Hemost. 2026 Sep 3. doi: 10.1055/a-2943-7750. PMID: 42692078. Abstract Clinical prediction scores have been central […]

Thrombophilia

Monitoring ADAMTS13 Deficiency: An Expert Rev. Hematology Review

Here is a current open-access article about ADAMTS13 deficiency: Binder NB, Depasse F, Spannagl M, et al. Clinical laboratory diagnostics and monitoring of ADAMTS13 deficiency and of related diseases: an integrated approach. Expert Rev Hematol. 2026 Sep;19(9):1037-1057. doi: 10.1080/17474086.2026.2702550. PMID: 42461718. Abstract Introduction: ADAMTS13, a crucial enzyme in hemostasis that specifically cleaves von Willebrand factor […]

Bleeding Disorders

September 2026 QQ: Anticoagulant Therapy for LAC Patients with VTE

Our September 2026 Quick Question is a poll that asks: In your facility, what AC is used for LAC patients with VTE? Anti-Xa DOAC Anti-IIa DOAC Warfarin Aspirin None AC therapy is indicated for VTE, including VTE and fetal loss associated with the presence of chronic LAC in the plasma. The commonly used anti-FXa DOACs […]

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Anticoagulant Therapy

Aug 31 2026

george

World Thrombosis Day

World Thrombosis Day takes place every year on October 13, the birthday of Rudolf Virchow, who was a pioneer in the pathophysiology of thrombosis. A German physician, pathologist, biologist, and anthropologist, Virchow developed the concept of “thrombosis” and advanced our understanding of this condition. He pioneered the modern concept of pathological processes by his application […]

Thrombophilia

Circadian Clock Regulates Hemostasis

This 2026 advanced open-access meta-analysis examines the effects of the circadian clock, accounting for the prevalence of morning strokes and AMIs. Ibrahim Z, Murphy RP, Guillaume GC, Arya R, Goswami N. Circadian clock regulation of hemostasis: a systematic review of molecular pathways. Res Pract Thromb Haemost. 2026 May 8;10(4):106642. doi: 10.1016/j.rpth.2026.106642. PMID: 42293739; PMCID: PMC13264353. […]

Arterial Thrombosis

Review: AI Designing the Future of Hemostasis

Check your medical library for this review article on AI-based peptide design to modify the GPIbα-VWF interaction in platelet-type von Willebrand disease: Kazmirchuk TDD, Wang J, Corbette J, et al. Designing the future of hemostasis. Semin Thromb Hemost. 2026 Jun 9. doi: 10.1055/a-2885-4368. PMID: 42225137. Abstract Bleeding disorders arising from dysfunctional platelet-protein interactions pose a […]

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Bleeding Disorders

Thrombophilia

Heparin Effect on Chemiluminescence HIT Testing

July 2026 CAP Today Q & A Column: Lipoprotein (a).

September 2026 QQ Summary: Anticoagulant Therapy for LAC Patients with VTE

Review: Pediatric VTE

Can AI Replace Clinical Prediction Scores in Thrombophilia?

Monitoring ADAMTS13 Deficiency: An Expert Rev. Hematology Review

September 2026 QQ: Anticoagulant Therapy for LAC Patients with VTE

World Thrombosis Day

Circadian Clock Regulates Hemostasis

Review: AI Designing the Future of Hemostasis

George Fritsma MS MLS

Cheat Sheets from George

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