Thrombophilia

DIC and Hemolysis

Anne D’ Agostino asks, “Should we reject hemolyzed samples from someone in DIC?” The simple answer is “do not reject,” because the hemolysis is likely intravascular, reflecting DIC‘s microangiopathic hemolytic anemia [MAHA]. But to elaborate, there’s no foolproof way to differentiate intravascular [in vivo] hemolysis from spurious [in vitro] hemolysis, the consequence of specimen collection […]

Bleeding Disorders

Poster: Effect of High-Dose DOACs and DOAC-Remove on LA Detection

Click here to see our ISTH poster, Rahman M, Sadeghi-Khomami A, Black KM. Effect of high-dose direct anticoagulant drugs and DOAC-Remove™ on lupus anticoagulant detection by a hexagonal phase phospholipid assay, 2023. [ISTH Abstract PB1147].

Specimen Management

Coag Conversation Part 3: VWF and ADAMTS13: Cardiovascular Diseases

Introducing The Many Faces of von Willebrand Factor or, von Willebrand Factor, ADAMTS13, Malignancy and Beyond Part 3: von Willebrand Factor and ADAMTS13; Thrombotic Mechanisms and Cardiovascular Diseases. This 30″ talk features George A. Fritsma, MS, MLS, proprietor of The Fritsma Factor, Your Interactive Hemostasis Resource, and Emmanual Favaloro, PhD, Principal Hospital Scientist at the […]

Arterial Thrombosis

CLN: Viscoelastometry Article

Here is a May 2023 Clinical Laboratory News cover review by colleague and fellow “clotter” Oksana Volod, MD, entitled “Is TEG the Right Assay? [click]” The article describes the updated means for near-patient viscoelastometry assays, whose original methodology became available in 1948. Clinical Laboratory News is a widely distributed American Association for Clinical Chemistry [AACC} […]

Global Hemostasis Assays

Familial APS?

On June 1 a Fritsma Factor participant asked if there were any evidence of a familial prevalence for symptomatic antiphospholipid syndrome [APS] or lab evidence for the familial distribution of one of the antiphospholipid antibodies [APAs]: lupus anticoagulant [LA], anti-cardiolipin antibody [ACA], or anti-beta-2-glycoprotein 1. I [Geo] located only a single case report: Bhattacharya S, […]

Lupus Anticoagulant

PERT Consortium

Thanks to Paul Riley, Ph.D., Diagnostica Stago, for his introduction to the Pulmonary Embolism Response Team [PERT] Consortium. For our list of hemostasis-related links, click here. If your association does not appear in the list, please provide the website and link to me [Geo] at [email protected].

Antiphospholipid Antibodies in Gulf War Syndrome

Thanks to hemostasis researcher Dave McGlasson for sending this article that indicates lupus anticoagulant as an autoimmunity mechanism associated with Gulf War Syndrome. James LM, Johnson RA, Lewis SM, et al. Lupus anticoagulant in Gulf War Illness and autoimmune disorders: a common pathway toward autoimmunity. J Immunological Sci. 2021; 5: 14–18. Dave had published a […]

Thrombotic Microangiopathies Presentation Handout

Click for the handout for “von Willebrand Factor, Friend or Foe,” which George presented on Friday, April 21, and Friday, April 29, 2023.

Arterial Thrombosis

Age-adjusted D-dimer Cutoff

From Amberly Nunez: Hi George, I am curious to see if anyone is using the age-adjusted D-dimer cutoff for PE? I know this topic was discussed in 2014 and wanted to see if there has been a practice change since that time. We are using the STA Liatest D-Di and our ED physicians have asked […]

Webinar: The Many Faces of VWF Part 1: Von Willebrand Factor and Acquired von Willebrand Syndrome

Fritsma Factor participants, we invite you to view Part 1 of our video: series ‘Coag Conversations’ The Many Faces of von Willebrand Factor; or Von Willebrand Factor, ADAMTS13, Malignancy, and Beyond: Von Willebrand Factor and Acquired von Willebrand syndrome, A Kaleidoscope of Presentations.” This is the first of a three-part series sponsored by BioMedica Diagnostics of […]

Arterial Thrombosis

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

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