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Thrombophilia

Sep 4 2026
george

Monitoring ADAMTS13 Deficiency: An Expert Rev. Hematology Review

Here is a current open-access article about ADAMTS13 deficiency: Binder NB, Depasse F, Spannagl M, et al. Clinical laboratory diagnostics and monitoring of ADAMTS13 deficiency and of related diseases: an integrated approach. Expert Rev Hematol. 2026 Sep;19(9):1037-1057. doi: 10.1080/17474086.2026.2702550. PMID: 42461718. Abstract Introduction: ADAMTS13, a crucial enzyme in hemostasis that specifically cleaves von Willebrand factor […]
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Bleeding Disorders
Aug 26 2026
george

Circadian Clock Regulates Hemostasis

This 2026 advanced open-access meta-analysis examines the effects of the circadian clock, accounting for the prevalence of morning strokes and AMIs. Ibrahim Z, Murphy RP, Guillaume GC, Arya R, Goswami N. Circadian clock regulation of hemostasis: a systematic review of molecular pathways. Res Pract Thromb Haemost. 2026 May 8;10(4):106642. doi: 10.1016/j.rpth.2026.106642. PMID: 42293739; PMCID: PMC13264353. […]
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Arterial Thrombosis
Aug 4 2026
george

Review: AI Designing the Future of Hemostasis

Check your medical library for this review article on AI-based peptide design to modify the GPIbα-VWF interaction in platelet-type von Willebrand disease: Kazmirchuk TDD, Wang J, Corbette J, et al. Designing the future of hemostasis. Semin Thromb Hemost. 2026 Jun 9. doi: 10.1055/a-2885-4368. PMID: 42225137. Abstract Bleeding disorders arising from dysfunctional platelet-protein interactions pose a […]
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Bleeding Disorders
Jul 15 2026
george

Risk of PE in Octogenarians

Here is a provocative open-access case-control article: Lipa AJ, Janata-Schwatczek K, Sterz M, et al. Too old for PESI?: risk stratification of octogenarians with pulmonary embolism in the emergency department. Semin Thromb Hemost. 2026. doi: 10.1055/a-2896-8297. PMID: 42361814. Abstract Pulmonary embolism (PE) in octogenarians (i.e., patients >80 years) is associated with substantial morbidity and mortality, yet […]
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Thrombophilia
Jul 13 2026
george

A LAC Assay that Resists DOAC Interference

Click Rahman M, Black KM, Sadeghi-Khomami A; An Automated Lupus Anticoagulant Assay Resistant to Anticoagulant Drugs Including DOACs and Oral FXI Inhibitors for a 2016 ISTH poster that documents an updated LAC assay. Background Direct oral anticoagulants (DOACs) and oral FXI inhibitors interfere with LAC testing by prolonging clotting times and increasing assay variability. Activated charcoal […]
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Anticoagulant Therapy
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George Fritsma MS MLS

George Fritsma is a medical laboratory scientist, educator, and author. George  is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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In your facility, what AC is used for LAC patients with VTE?