Quick Question Archive

April 2024 QQ: MYH9 Mutation

Molecular diagnostic methods have defined scores of platelet disorders that by phenotype alone were categorized as production or functional disorders. Our April 2024 Quick Question is a quiz that “scratches the surface” by asking what disorder or syndrome is part of the MYH9 gene mutation family. For a look at molecular diagnostics practical applications, see […]

Platelet Function Testing

March 2024 Quick Question Summary: Factor Deficiency

Our March 2024 Quick Question was a quiz. The question was, “What factor deficiency causes bleeding but doesn’t prolong the PT or PTT?” Our 75 respondents answered as follows: FVIII: 7 [9%] FIX: 3 [4%] FXI: 3 [4%] FXII: 8 [11%] FXIII: 54 [72%] Factor VIII, IX, XI, and XII deficiencies prolong the PTT but […]

Bleeding Disorders

March 2024 Quick Question: Factor Deficiency

Our March 2024 Quick Question, a factor deficiency quiz asks “What factor deficiency causes bleeding but doesn’t prolong the PT or PTT?” Please select the one correct answer and make additional comments below.

Bleeding Disorders

February 2024 Quick Question: Rosenthal Syndrome

Forty-two participants answered our February 2024 Quick Question, “What factor deficiency is named Rosenthal syndrome?” Here are the answers: FV: 3 [7%] FVII: 2 [5%] FX: 2 [5%] FXI: 28 [67%] FXII: 5 [11%] FXIII: 2 [5%] Most of us correctly chose factor XI deficiency, Rosenthal Syndrome. FXI deficiency is an autosomal recessive hemophilia with […]

Bleeding Disorders

Feb 2024 Quick Question: Rosenthal Syndrome

Our February 2024 Quick Question is a quiz that tests the knowledge we gained in our entry-level coagulation courses. At the end of February, we’ll use this as a means to discuss the efficacy of currently available DOACs and some new developments.

Coagulation Factors

January 2024 Quick Question Response: Platelet Function Tests

Fritsma Factor’s January 2024 Quick Question asks, “What platelet function test do you use?” Our 43 participants responded… Light transmittance aggregometry: 15 [35%] Whole blood aggregometry: 7 [16%] Lumiaggregometry: 8 [19%] Bleeding time: 0 PFA 100/200: 13 [30%] Presuming that those who chose the lumiaggregometry entry perform theirs on an impedance-based whole blood aggregometer, we […]

Quick Question Archive

January 2024 Quick Question: Platelet Function Tests

Our January 2024 question is a poll submitted by Dave McGlasson, asking, “What platelet function test do you use?” While light transmittance aggregometry [LTA] has been available since the mid-1960s and is regarded by many as the reference method for platelet function testing, many have switched to the simpler whole blood aggregometry [WBA]. Our answers […]

Bleeding Disorders

December 2023 Quick Question Summary: VWD Subtype 2B

Our December 2024 Quick Question, “How do you test for VWD subtype 2B?” attracted 31 responses as follows: RIPA: 15 [48%] VWFAg: 2 [7%] VWF:CB: 5 [16%] VWF:RCo: 6 [19%] Multimeric analysis: 3 [10%] Our question drew this comprehensive discussion from Dr. Emmanuel Favaloro on Tuesday, December 12, 2023: Hi George, I have been following […]

Bleeding Disorders

December 2023 Quick Question: VWF Subtype 2B

Our December 2023 Quick Question asks, “How do you test for VWD subtype 2B?” This is in follow-up to our February 2023 question, “What VWF activity assay do you use?” VWD subtype 2B is a qualitative VWF deficiency caused by a gain-of-function mutation that increases VWF-platelet-binding avidity. Please answer the quiz and post your comments […]

Bleeding Disorders

November 2023 Quick Question: Platelet Hyperaggregability Summary

Our modest 15-player response to the November 2023 Quick Question poll implies a scant interest in platelet hyperaggregability, the outcome of an October 4 post by Mayukh Sarkar, PhD. “Sticky Platelet Syndrome.” Question: Do you test for platelet hyperaggregation? No, there’s no such thing: 6 [40%] Yes, we call it “sticky platelets:” 6 [40%] We […]

Arterial Thrombosis

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

Cheat Sheets from George

Quick Question