Aspirin v. Clopidogrel in Dual Antiplatelet Therapy

Obtain this article from your medical library: Rubboli A, Pompei G, De Rosa S, et al. Clopidogrel vs. aspirin in addition to oral anticoagulation as part of double antithrombotic therapy following PCI: a post-hoc analysis of the PERSEO registry. J Thromb Thrombolysis. 2026 Apr 20. doi: 10.1007/s11239-026-03286-4. PMID: 42008084. Abstract In patients on oral anticoagulation […]

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Antiplatelet Therapy

May 8 2026

george

Aspirin Prophylaxis

The question appeared on the Diagnostic Equity site, paraphrased with the approval of site proprietor Tamara Lobban-Jones: “I’ve heard that some people take a ‘ton of baby aspirin.’ My doc told me to take only one a day. Does taking multiple tablets help with clotting? What does taking one aspirin do to the blood, and […]

Antiplatelet Therapy

Platelet-inflammation Interactions

Click here for a provocative open-access article describing the now established relationship between platelets and inflammatory processes: Escaig R, Kreutz L, Kaiser R, Nicolai L. Platelet effector functions in inflammation. Res Pract Thromb Haemost. 2026;10:103412. doi: 10.1016/j.rpth.2026.103412. PMID: 42027308; PMCID: PMC13100282. Abstract A State of the Art lecture titled “Platelet effector functions in inflammation” was […]

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Platelet Function Testing

Feb 13 2026

george

What is Red Light Therapy?

Check with your medical library for this in-depth review of red light Rx efficacy: Fan BE, Pasalic L, Hew YY, Lippi G, Favaloro EJ. Red light therapy in thrombosis and hemostasis. Semin Thromb Hemost. 2026;52:266–72. doi: 10.1055/a-2717-5157. PMID: 41062078. Abstract Red light therapy is emerging as a potential non-pharmacological modulator of thrombosis and hemostasis. Photobiomodulation […]

Antiplatelet Therapy

Red Light Therapy in Hemostasis and Thrombosis

Check with your medical library for an advanced study of the effects of red light therapy upon hemostasis: Fan BE, Pasalic L, Hew YY, Lippi G, Favaloro EJ. Red light therapy in thrombosis and hemostasis. Semin Thromb Hemost. 2025. doi: 10.1055/a-2717-5157. Epub ahead of print. PMID: 41062078. Abstract Red light therapy is emerging as a […]

Antiplatelet Therapy

Bleeding Time

I (Geo) received this question on May 23, 2025: “I am using 100 mg of aspirin and 75 mg of Plavix. My PTT is 35.8 seconds; PT 13.8 seconds, INR 1.18; bleeding time is 1 minute and 30 seconds; clotting time is 8 minutes. Are these results normal when using the two drugs together?” I […]

Antiplatelet Therapy

A Molecular Approach to Assess Platelet Hyperreactivity

Friend Ed Groenendal forwarded this UPI summary of a molecular approach correlating evidence of hyperresponsive platelets to major adverse cardiac or limb events. The investigators started with aggregometry-defined platelet hyperreactivity to apply a transcriptome-based platelet reactivity expression score (PRESS). Click below to see the detailed open-access article describing the development and application of the PRESS. […]

Antiplatelet Therapy

Mixing Studies and Various Therapeutics

From Leslie Chaparro: We recently had a patient who had a mixing study ordered but who had recently taken tranexamic acid [TXA]. We exclude patients that have been on anticoagulants but have never really considered drugs that encourage clotting. How would this affect the patient’s mixing study? How do we keep up with all the […]

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Anticoagulant Therapy

Jan 30 2022

george

February, 2022 Quick Question: Platelet Aggs

Our February 2022 Quick Question asks, What single agonist is your first choice to measure platelet response to aspirin? The typical aggregation profile includes several agonists, however it may be that one is more sensitive to aspirin’s antiplatelet effect than the others. As always, please add your comments below.

Antiplatelet Therapy

Primary CVD Disease: Is Low Dose ASA Effective?

Thanks to Dean Willett, Precision BioLogic Inc, for pointing me to this October 12, 2021 US Preventive Services Task Force release, “Aspirin Use to Prevent Cardiovascular Disease: Preventive Medication,” which recommends against daily low-dose aspirin as a means to reduce the risk of cardiovascular disease, ischemic stroke, and colorectal cancer regardless of age or comorbities. […]

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Antiplatelet Therapy

Antiplatelet Therapy

Aspirin v. Clopidogrel in Dual Antiplatelet Therapy

Aspirin Prophylaxis

Platelet-inflammation Interactions

What is Red Light Therapy?

Red Light Therapy in Hemostasis and Thrombosis

Bleeding Time

A Molecular Approach to Assess Platelet Hyperreactivity

Mixing Studies and Various Therapeutics

February, 2022 Quick Question: Platelet Aggs

Primary CVD Disease: Is Low Dose ASA Effective?

George Fritsma MS MLS

Cheat Sheets from George

Questions or Comments?

Quick Question