Aug 23 2024
Friend Ed Groenendal forwarded this UPI summary of a molecular approach correlating evidence of hyperresponsive platelets to major adverse cardiac or limb events. The investigators started with aggregometry-defined platelet hyperreactivity to apply a transcriptome-based platelet reactivity expression score (PRESS). Click below to see the detailed open-access article describing the development and application of the PRESS.
Following up on Dr. Favaloro’s comment below, here are two open-access articles that he cited:Mammen EF. Sticky platelet syndrome. Semin Thromb Hemost. 1999;25:361-5. doi: 10.1055/s-2007-994939.
In addition, these cited articles are available from Seminars in Thrombosis and Hemostasis and Expert Reviews in Hematology, respectively:
Kubisz P, Holly P, Stasko J. Sticky platelet syndrome: 35 years of growing evidence. Semin Thromb Hemost. 2019;45:61–8. doi: 10.1055/s-0038-1676581.
Stasko J, Holly P, Kubisz P. A new decade awaits sticky platelet syndrome: where are we now, how do we manage and what are the complications? Expert Rev Hematol. 2022;15):53–63. doi: 10.1080/17474086.2022.2030217. Epub 2022 Jan 31. PMID: 35034520.
Comments (1)
Antiplatelet Therapy
Hi George, seems a little reminiscent of the ‘sticky platelet syndrome’ characterized by Eberhard F Mammen and others in the mid 1970’s? For anyone interested in revisiting the past, please see PubMed IDs: 10548069, 30630203, 30630207, 35034520