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June 2026 QQ: VWF Gain of Function

In keeping with our “100 Years of VWD” theme, our June 2026 Quick Question, which appears in the right-hand column, asks, “What VWD subtype is caused by a VWF gain of function?” Gain of function refers to VWF with enhanced binding avidity to the platelet GP1b binding site. For assistance, navigate to our Informative Module, […]

Quick Question Archive

What is CAPS?

Here is an illustrated Hemostasis Today description by Dr. Abdul Mannan, Consultant Haematologist at Betsi Cadwaladr University Health Board, of catastrophic antiphospholipid syndrome (CAPS), which accounts for 1% of antiphospholipid syndrome (APS) diagnoses. As Dr. Mannan reports, the APL assay is a vital diagnostic consideration of this acute condition.

Lupus Anticoagulant

Coag Conversation: 100 Years of Von Willebrand Disease and Upcoming Advances

Click here for the first of our three-part Coag Conversation series, 100 Years of von Willebrand disease. featuring George Fritsma interviewing Robert Sidonio, MD. Dr. Sidonio is the Medical Director of the Clinical Research Office at the Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta and is the Professor of Pediatrics, Emory […]

Bleeding Disorders

FXI Deficiency and LAC

Sacha Uljon, MD, PhD, Medical Director, Core Laboratory, Massachusetts General Hospital, sent this provocative question on 6-10-2026. Hello–just an update. This has been frustrating–others also have issues distinguishing FXI deficiency from LAC. Here is one report available from your medical library: Rabichow L, Dinh J, Nguyen L, Qiao J. In vitro differential inhibition of the […]

Emergency Hemorrhage Hemostasis Profile

Cristina Figueroa Villalba, MD, authored a provocative editorial, When minutes matter: the laboratory’s role in rapid hemostasis assessment in the May/June issue of CLN, a publication of ADLM. Please review this 10-minute read and respond with your recommendations for a rapid-test profile for acute hemorrhage. For instance, would you include a PTT, the DOASENSE® urinary […]

Bleeding Disorders

VTE in Sickle Cell Disease

Click this open-access 2026 article for a retrospective review of individuals with sickle cell disease to identify those who developed VTE. Bhasin N, Zhang L, Ajayi A, et al. Risk factors for venous thromboembolism in sickle cell disease. Res Pract Thromb Haemost. 2026;10(3):103454. doi: 10.1016/j.rpth.2026.103454. PMID: 42027307; PMCID: PMC13099461. Abstract Background: Individuals with sickle cell […]

Factor XIII and Clot Stability

Click here for an open-access illustrated discussion via Hemostasis Today by Abdul Mannan of the multiple roles of FXIII and the adverse effects of FXIII deficiency related to wound healing and clot integrity.

June 2026 Cheat Sheet

Click here for your June 2026 Fritsma Factor Cheat Sheet. If you would like a “push” copy of this Cheat Sheet, complete with links to our numerous May posts, please complete the application form on the right. The Cheat Sheet is published on the first of each month and is a gratis premium of Precision BioLogic […]

May 2026 QQ: “Proconvertin” Response

Our May 2026 Quick Question was a quiz and a “walk down memory lane.” Our 28 responders to the lead, “What factor was once named Proconvertin or SPCA?” responded as follows: IV: 2 (7%) V: 4 (14%) VI: 1 (4%) VII: 18 (64%) IX: 3 (11%) We’ve largely abandoned our proper noun terminology except for […]

Quick Question Archive

“Covid Coag”

On May 26, I (Geo) posted a link to our informational module, The Cell-based Coagulation Model. On May 15, I posted a link to our Coagulation Overview Module. The third in a series of “Mechanism” modules, and perhaps the most complex, is entitled Covid Coag. Though thanks to vaccination technology, we think less today about […]

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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