Nov 13 2026

george

Two Patients–Same Diagnosis, Same Anti-Xa Result. Does It Mean The Same Thing?

Navigate to an informative LinkedIn case study about Anti-Xa results posted by coagulation specialist Ifeanyichukwu Ifechidere.

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Anticoagulant Therapy

Nov 10 2026

george

Study: Adverse Effects of DOACs in Pregnancy

Click here for this open-access article describing pregnancy loss and fetal defects in anticoagulation: Dao K, Beck E, Pizzoglio-Billaudaz V, et al. Reproductive safety of direct oral anticoagulants after maternal exposure in early pregnancy: a comparative European Network of Teratology Information Services cohort study. J Thromb Haemost. 2026:S1538-7836(26)00572-6. doi: 10.1016/j.jtha.2026.08.037. PMID: 42744052. Abstract Background: Direct […]

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Anticoagulant Therapy

Nov 10 2026

george

News Release: The first Anti-XIa Antithrombotic Cleared 11-9-26

Click for Bayer’s news release describing the efficacy and safety data for asundexian anti-XIa stroke therapy.

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Anticoagulant Therapy

Nov 5 2026

george

Anti-XIa Anticoagulant Ineffective in Phase 3 Trial

Check your local medical library for the disappointing results of a phase 3 Milvexian (anti-XIa) trial  Gibson CM, Steg PG, Bahit MC, et al. LIBREXIA ACS Committees and Investigators. Milvexian with antiplatelet therapy after an acute coronary syndrome event. N Engl J Med. 2026;395(16):1575–84. doi: 10.1056/NEJMoa2608717. PMID: 42670965. Abstract Background Patients are at increased risk […]

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Anticoagulant Therapy

Nov 2 2026

george

Clinical Anticoagulant Measurement

Check your local medical library for these anticoagulation measurement reviews published in the November 2026 issue of Seminars in Thrombosis and Hemostasis: Favaloro EJ, Reardon B, Pasalic L. Laboratory monitoring and measuring of clinical anticoagulants. Semin Thromb Hemost. 2026;52(8):927–36. doi: 10.1055/a-2907-8841. PMID: 42442704. Abstract Haemostasis reflects a balance between procoagulant and anticoagulant forces. A relative […]

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Anticoagulant Therapy

Oct 28 2026

george

Illustrated Review: History of Anticoagulant Pharmacology

Here’s an open-access illustrated review that includes FXI and FXII inhibitors currently in development: Wichaiyo S. Pharmacology of anticoagulants: from heparin to novel target-specific agents. J Thromb Haemost. 2026:S1538-7836(26)00486-1. doi: 10.1016/j.jtha.2026.08.001. PMID: 42567362. Abstract Anticoagulants are the drugs of choice for the management of various thromboembolic disorders affecting both arteries and veins. This review delineates […]

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Anticoagulant Therapy

Oct 23 2026

george

Can We Confirm a DOAC Overdose?

Here’s a provocative question from Sacha N. Uljon, MD, PhD, Medical Director, Massachusetts General Brigham Special Coagulation Integrated Laboratory Service: Hello, this post is about lab findings in apixaban overdose. We have now seen two suicide attempts involving apixaban. There was no clot at all on the PT/PTT (Werfen/Hemosil), so the anti-Xa level can’t be […]

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Anticoagulant Therapy

Oct 20 2026

george

Reduced-dose DOACs in Cancer-associated Thrombosis

Click for this open-access retrospective cohort study reporting the safety and efficacy outcomes for reduced-dose DOACS: Santini P, Santagata D, Mosoni C, et al. Full- versus reduced-dose direct oral anticoagulants for extended treatment of cancer-associated thrombosis: a multicenter retrospective cohort study. Semin Thromb Hemost. 2026. doi: 10.1055/a-2904-5824. PMID: 42379243. Abstract Extended anticoagulation is recommended in […]

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Anticoagulant Therapy

Oct 12 2026

george

Heparin Effect on Chemiluminescence HIT Testing

Check with your local library for this HIT testing report: Vong R, Pasalic L, Donikian D, Brighton T, Favaloro EJ. Effect of heparin on immunological heparin-induced thrombocytopenia-IgG chemiluminescence testing. Blood Coagul Fibrinolysis. 20261;37(7):329-335. doi: 10.1097/MBC.0000000000001456. PMID: 42615582. Heparin-induced thrombocytopenia (HIT) requires clinical evaluation and laboratory testing using immunological assays with confirmation by functional assays such […]

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Anticoagulant Therapy

Oct 9 2026

george

The ISTH Pulse Podcast Series: Anti-factor XIa Antithrombotics

Select ISTH: The Pulse Podcast to access a series of presentations that describe the emerging anti-FXIa antithrombotics. The site requests registration.

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Anticoagulant Therapy