Register Login

Anticoagulant Therapy

Sep 16 2026
george

Heparin Re-exposure in HIT Patients

Obtain this article about HIT from your local medical library: Caudill EB, Kim JH, Kanaan DM, Sylvester KW, Pimentel LY, Kim CS, Connors JM. Heparin re-exposure in patients with a history of heparin-induced thrombocytopenia. J Thromb Haemost. 2026 Aug 3:S1538-7836(26)00484-8. doi: 10.1016/j.jtha.2026.07.024. PMID: 42546848. Objective To evaluate heparin re-exposure practices and safety in patients with […]
read more
Comments (0)
Anticoagulant Therapy
Aug 24 2026
george

DOAC Pharmacodynamics and Potential Near-patient Decision Making

Access your ISTH membership or medical library for a ground-breaking JTH Forum article: Shaw JR, Ansell J. A light in the dark-reframing direct oral anticoagulant pharmacokinetics and pharmacodynamics for near-patient decision-making. J Thromb Haemost. 2026;24(8):2726-2731. doi: 10.1016/j.jtha.2026.05.016. Epub 2026 May 21. PMID: 42173287. Abstract Direct oral anticoagulant (DOAC) level testing is needed most when decisions […]
read more
Comments (0)
Anticoagulant Therapy
Aug 17 2026
george

Simplified DOAC–Stop Proof of Concept

Click here for this 2024 open-access article describing the use of DOAC-Stop®: Exner T, Dangol M, Favaloro EJ. Simplified method for removing direct oral anticoagulant interference in mechanical coagulation test systems–a proof of concept. J Clin Med. 2024;13:1042. doi: 10.3390/jcm13041042. PMID: 38398355; PMCID: PMC10889288. Abstract Background: Direct oral anticoagulants (DOACs) cause unwanted interference in various […]
read more
Comments (0)
Anticoagulant Therapy
Jul 14 2026
george

Review: Laboratory Monitoring and Measuring of Clinical Anticoagulants

Check your medical library for this July, 2026 review: Favaloro EJ, Reardon B, Pasalic L. Laboratory monitoring and measuring of clinical anticoagulants. Semin Thromb Hemost. 2026. doi: 10.1055/a-2907-8841. PMID: 42442704. Abstract Haemostasis reflects a balance between procoagulant and anticoagulant forces. A relative excess of procoagulant forces and/or a relative lack of anticoagulant forces can predispose […]
read more
Comments (0)
Anticoagulant Therapy
Jul 13 2026
george

A LAC Assay that Resists DOAC Interference

Click Rahman M, Black KM, Sadeghi-Khomami A; An Automated Lupus Anticoagulant Assay Resistant to Anticoagulant Drugs Including DOACs and Oral FXI Inhibitors for a 2016 ISTH poster that documents an updated LAC assay. Background Direct oral anticoagulants (DOACs) and oral FXI inhibitors interfere with LAC testing by prolonging clotting times and increasing assay variability. Activated charcoal […]
read more
Comments (0)
Anticoagulant Therapy
Load more

George Fritsma MS MLS

George Fritsma is a medical laboratory scientist, educator, and author. George  is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

read more

Cheat Sheets from George

Name

Questions or Comments?

Email George

Quick Question

Which is NOT an antiphospholipid antibody?