Sep 2 2026

george

PT/INR and PTT Therapeutic Levels

From Jessica Warner, Kettering Health: Hi George, I was wondering whether there has ever been a discussion about evaluating these ranges and whether there’s a consensus on what they should be. I have been in my job for 12 years and never looked at them to change them until an AC at another health system […]

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Anticoagulant Therapy

Aug 31 2026

george

September 2026 QQ: Anticoagulant Therapy for LAC Patients with VTE

Our September 2026 Quick Question is a poll that asks: In your facility, what AC is used for LAC patients with VTE? Anti-Xa DOAC  Anti-IIa DOAC  Warfarin  Aspirin  None AC therapy is indicated for VTE, including VTE and fetal loss associated with the presence of chronic LAC in the plasma. The commonly used anti-FXa DOACs […]

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Anticoagulant Therapy

Aug 24 2026

george

DOAC Pharmacodynamics and Potential Near-patient Decision Making

Access your ISTH membership or medical library for a ground-breaking JTH Forum article: Shaw JR, Ansell J. A light in the dark-reframing direct oral anticoagulant pharmacokinetics and pharmacodynamics for near-patient decision-making. J Thromb Haemost. 2026;24(8):2726-2731. doi: 10.1016/j.jtha.2026.05.016. Epub 2026 May 21. PMID: 42173287. Abstract Direct oral anticoagulant (DOAC) level testing is needed most when decisions […]

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Anticoagulant Therapy

Aug 17 2026

george

Simplified DOAC–Stop Proof of Concept

Click here for this 2024 open-access article describing the use of DOAC-Stop®: Exner T, Dangol M, Favaloro EJ. Simplified method for removing direct oral anticoagulant interference in mechanical coagulation test systems–a proof of concept. J Clin Med. 2024;13:1042. doi: 10.3390/jcm13041042. PMID: 38398355; PMCID: PMC10889288. Abstract Background: Direct oral anticoagulants (DOACs) cause unwanted interference in various […]

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Anticoagulant Therapy

Jul 29 2026

george

Better Managed Anticoagulation

Click Edward Lee Carter, BSPharm BPP‘s Better Calibrated Anticoagulation LinkedIn summary from the recent ISTH meeting that describes the need for managing the risks of anticoagulant therapy through lab measurement and monitoring outcomes.

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Anticoagulant Therapy

Jul 28 2026

george

August 2025 QQ: Coagulation Control Proteins

Our August 2026 Quick Question is a simple quiz that asks, “Which is NOT an endogenous coag control protein?” This is your opportunity to review the plasma-based coagulation mechanism and recall the functions of the control proteins, available in our Educational Module entitled Coagulation Overview. One of these is NOT an endogenous control protein for […]

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Quick Question Archive

Jul 14 2026

george

Review: Laboratory Monitoring and Measuring of Clinical Anticoagulants

Check your medical library for this July, 2026 review: Favaloro EJ, Reardon B, Pasalic L. Laboratory monitoring and measuring of clinical anticoagulants. Semin Thromb Hemost. 2026. doi: 10.1055/a-2907-8841. PMID: 42442704. Abstract Haemostasis reflects a balance between procoagulant and anticoagulant forces. A relative excess of procoagulant forces and/or a relative lack of anticoagulant forces can predispose […]

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Anticoagulant Therapy

Jul 13 2026

george

A LAC Assay that Resists DOAC Interference

Click Rahman M, Black KM, Sadeghi-Khomami A; An Automated Lupus Anticoagulant Assay Resistant to Anticoagulant Drugs Including DOACs and Oral FXI Inhibitors for a 2016 ISTH poster that documents an updated LAC assay. Background Direct oral anticoagulants (DOACs) and oral FXI inhibitors interfere with LAC testing by prolonging clotting times and increasing assay variability. Activated charcoal […]

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Anticoagulant Therapy

Jul 6 2026

george

External Quality Assessment for Anti-FXa LMWH Assays

Check with your local medical library for this thought-provoking article: Favaloro EJ, Arunachalam S, Pasalic L. External quality assessment for low molecular weight heparin monitoring in the Australasia/Asia-Pacific region. Semin Thromb Hemost. 2026. doi: 10.1055/a-2900-7026. Epub ahead of print. PMID: 42398957. Abstract LMWH remains a widely used parenteral anticoagulant in hospital and outpatient settings for […]

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Anticoagulant Therapy

Jul 6 2026

george

What is Anticoagulation Drift?

Click to read this LinkedIn post, where Edward Lee Carter, BSPharm, CPP, states: “The greatest threat to long-term anticoagulation may not be choosing the wrong drug. It may be failing to recognize that the patient has changed.” He illustrates the value of clinical laboratory assays to periodically confirm DOAC dosages.

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Anticoagulant Therapy