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February, 2022 Quick Question: Platelet Aggs

Our February 2022 Quick Question asks, What single agonist is your first choice to measure platelet response to aspirin? The typical aggregation profile includes several agonists, however it may be that one is more sensitive to aspirin’s antiplatelet effect than the others. As always, please add your comments below.

Comments (2)
Antiplatelet Therapy
Dec 8, 2022 9:38pm

I agree with Dave McGlasson that arachidonic acid induced aggregation is the most sensitive to aspirin. However, AA is the least stable of the reagents used to test for platelet function. I also rely on 5 uM ADP. If I see a less than normal response to this concentration of ADP (including disaggregation) with no response to AA, then I am comfortable that aspirin is responsible.

Feb 2, 2022 9:55am

i would always stat with a
I would always start with a concentration of arachidonic acid for measuring the effect of aspirin on platelet aggregation. See McGlasson DL, Fritsma GA. Comparison of four laboratory methods to assess aspirin sensitivity. Blood Coag Fibrinolysis 2008; 19:120–3 and Schwertner HA, McGlasson DL, Bush A. Effects of different aspirin formulations on platelet aggregation times and on plasma salicylate concentrations. Thrombosis Research 2006; 118: 529–34.

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