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February, 2022 Quick Question: Platelet Aggs

Our February 2022 Quick Question asks, What single agonist is your first choice to measure platelet response to aspirin? The typical aggregation profile includes several agonists, however it may be that one is more sensitive to aspirin’s antiplatelet effect than the others. As always, please add your comments below.

Comments (1)
Antiplatelet Therapy
davemcglasson
Feb 2, 2022 9:55am

i would always stat with a
I would always start with a concentration of arachidonic acid for measuring the effect of aspirin on platelet aggregation. See McGlasson DL, Fritsma GA. Comparison of four laboratory methods to assess aspirin sensitivity. Blood Coag Fibrinolysis 2008; 19:120–3 and Schwertner HA, McGlasson DL, Bush A. Effects of different aspirin formulations on platelet aggregation times and on plasma salicylate concentrations. Thrombosis Research 2006; 118: 529–34.

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