Welcome to 2023. Our December 2022 Quick Question, which drew 45 responses, asks, “What parameter is NOT part of your thrombosis risk factor profile? The answers were:
- Antithrombin [1, 3%]
- Protein C [3, 7% ]
- Protein S [1, 2%]
- Prothrombin 20210 mutation [1, 3%]
- Lipoprotein [a] [38, 85%]
As anticipated, most of us have dropped, or never added, Lp [a] to our thrombosis risk profile, perhaps because even though an association with atherosclerosis has been confirmed, there has never been an effective therapeutic to reduce Lp [a] alone, thus no means to demonstrate that reduction provides a clinical advantage.
A November 28, 2022 Medscape conversation featuring Michelle L. O’Donoghue, MD, MPH, and Stephen J. Nicholls, MBBS, PhD discusses new methods that appear to reduce Lp [a] and provide a potential improvement in atherosclerotic cardiovascular disease, MI, stroke, and aortic valve disease. Click the citation below for the interview.