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Rodak: Clinical Principles and Applications

I would like to order two copies of Rodak BF, Fritsma GA, Keohane EM, Hematology; Clinical Principles and Applications, 4th Edition, 2011. How much would the total be, including shipping and handling? And could you please provide me with all of the ordering information to include ISBN number. Thank you, Winston Williams. Wonderful! I can advertise […]

Online Audio Seminars: LEND

George provided a new online seminar for the Laboratory Education for North Dakota network entitled “Managing Hemostasis in Trauma.” This is one of ten narrated PowerPoint seminars in all areas of laboratory medicine, available for a $60.00 registration fee. Contact Chris Triske, [email protected], for additional information.

Alteplase and Fibrinogen Assay

I cannot find much information about how Alteplase (Activase, synthetic tissue plasminogen activator, TPA) therapy affects fibrinogen assays. Are there any guidelines or references for specimen acceptability (time from collection) for coagulation testing when Alteplase is in use? Thanks. Carla Purvis MT (ASCP)SH Parkview Health System, Fort Wayne, IN Hi, Carla, and thanks for your question. […]

More on Transient LAs in Inflammation

George, The data in the paper I am writing about DVT and its treatment with tPA showed that 19 of 30 acute DVT patients had positive lupus anticoagulants at the time of presentation, of which 11 had resolved by 6-8 weeks of follow-up, and 2 were documented to be persistently positive 6 months later (the balance were […]

CAP Today; January, 2011

In case you haven’t seen it, there is an excellent article on coagulation testing basicsby Dr. William Check in the January CAP Today. It is the cover story and featuresDorothy M. (Adcock) Funk, MD, Medical Director and Laboratory Director, Esoterix Coagulation, John D. Olson, MD, PhD, Director of Clinical Laboratories, University of Texas Health Science Center, and Kandice Kottke-Marchant, MD, […]

Updates on Dysfibrinogenemia and the PT

Here’s a small addition to Dr. Jay Lozier’s Tuesday, February 1 discussion of a patient with dysfibrinogenemia whose prothrombin time (PT) was prolonged and would not correct in a mixing study. Dr. Lozier commented as follows in a return email sent the same day: “I thought that perhaps there would be fibrin split products that are preventing coagulation from […]

Hematology: Clinical Principles and Applications, 4th Edition

Forgive my blatant self-promotion, however I’d like to announce the February 16, 2011 release of our new textbook; Rodak BF, Fritsma GA, and Keohane EM, Hematology, Clinical Principles and Applications, 4th Edition, Elsevier-Saunders, 2011. Contributors to the coagulation sections include Larry D. Brace, Margaret G. Fritsma and David L. McGlasson, who also contribute to Fritsma Factor. Prior contributors to the coagulation […]

PT Mix Fails to Correct in Dysfibrinogenemia

Here is another thought-provoking email from Dr. Jay Lozier at the NIH. I need some expert help with this one. From Dr. Lozier: “I am in the position of hematology consultant who runs the coag lab. We see some interesting cases from time to time. I see a fair amount of storage pool deficiency that we diagnose […]

Still More on False Positive Hex-phase Phospholipids

The topic of hex-phase phospholipid neutralization tests that turn up positive for lupus anticoagulant in people who have specific anti-factor VIII inhibitors keeps coming back. Here is a comment from Dr. Jay Lozier of the NIH that takes us down a new pathway, the prevalence of transient lupus anticoagulants during acute inflammatory events… Dear George, I have recently stumbled upon your […]

Answers to RVV Questions

Back to our earlier discussion of the old Russell viper venom time (RVV, not the “new” dilute Russell viper venom time, DRVVT). Joe Lamb came up with the name, Stypven Time. The purpose was to differentiate between a factor VII deficiency (prothrombin time prolonged, DVV normal) and factor X deficiency (both long). With improvements to the partial thromboplastin time and […]

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

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