Factor Assays

Chromogenic Factor IX Assay Validation

Click below for a poster that was presented at the Thrombosis and Hemostasis Summit of North America [THSNA], August 16–18, 2022 that features a recently released chromogenic factor IX assay: Quinton T, Fraser J, Black KM, Sadeghi-Khomami A. Validation of a new kit for the determination of factor IX activity, Poster 418, Precision BioLogic Inc., […]

Bleeding Disorders

ISTH Poster: FVIII Deficient Plasma with VWF

Yesterday, July 12, 2022, at the ISTH annual meeting in London, England, the research staff of Precision BioLogic Inc., Dartmouth, Nova Scotia, Canada presented the poster: Kesavan N, Rahman M, Sadeghi-Khomami A, Black KM, Wood A. Performance of FVIII deficient plasma with VWF in the activity measurement of FVIII replacement products in plasma samples using […]

Bleeding Disorders

ISTH Poster: Chromogenic FIX Activity Assay

Yesterday, July 12, 2022, at the ISTH annual meeting in London, England, the research staff of Precision BioLogic Inc., Dartmouth, Nova Scotia, Canada presented the poster: Quinton T, Fraser J, Black KM, Sadeghi-Khomami A. Performance of a chromogenic factor IX activity assay in the recovery of factor IX replacement therapies, Abstract PB1183. Their data illustrate […]

Bleeding Disorders

Chromogenic Factor IX Assay

On May 9, 2022, Precision BioLogic, Inc. [PBI] announced the release and international approval for their chromogenic factor IX assay. Click here for PBI’s press release. The product addresses the key need for accuracy when monitoring extended half-life coagulation factor concentrate therapy.

Bleeding Disorders

November 2021 QQ: Case Study, Prolonged PTT, Response

Our November 2021 Quick Question Case attracted 75 responses. We asked, “A 3-YOA female with normal PT and prolonged PTT and no bleeding. What is the most likely deficiency?” Here are your responses: Factor V–3 [4%] Factor VIII–18 [20%] Factor IX–2 [3%] Factor XI–4 [7%] Factor XII–44 [59%] Factor XIII–4 [7%] Congenital factor V deficiency […]

Coagulation Factors

November 2021 Quick Question: Case Study, Prolonged PTT

Our November 2021 Quick Question involves a 3-year-old female patient with no bleeding history whose pre-op PT and PTT results were PT 13.3 seconds [RI 12-6–14.6] and PTT 51 seconds [RI 25–35] and asks what is the most likely coagulation factor deficiency. Please select your answer and add your comments below.

May, 2021 Quick Question: Flaujeac Factor Response

Our May, 2021 Quick Question was a historical factor name challenge, “What is the more common name for Flaujeac factor?” The question drew 24 responses. We answered: Hageman factor: 21% [5] Fletcher factor: 4% [1] Fitzgerald factor: 58% [14]X Stuart factor: 13% [3] Fibrinogen: 4% [1] High molecular weight kininogen [HMWK] was given the name […]

Extended Half-life FVIII & FIX and the PTT

From Carolyn McCarville: Hi George, My small laboratory is trying to figure out the best management of coag samples from patients receiving extended half life factor replacement products. We understand that many of the one stage clotting factor assays are inaccurate for the wealth of these products. One thing that we cannot get a straight […]

Bleeding Disorders

Covid and Lupus Anticoagulant

Two compelling publications appear to implicate lupus anticoagulant as a key factor in prolonged PTT results documented in seriously ill Covid victims. These could account for prolonged PTTs in the absence of hemorrhage. They are: Bowles L, Platton S, Yartey N, et al. Lupus anticoagulant and abnormal coagulation tests in patients with Covid-19. Downloaded from […]

New FVIII Inhibitor Assay

An exciting news release from Precision BioLogic Inc. Today, we are announcing the availability of our new CRYOcheck Factor VIII Inhibitor Kit in Canada, the European Union, Australia, and New Zealand following market authorization by Health Canada and respective in-country regulatory authorities in January. Click here for full information about the CRYOcheck Factor VIII Inhibitor […]

Bleeding Disorders

Load more

George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

Cheat Sheets from George

Quick Question