Oct 18 2022
From “Kaarin,” We are wondering what other labs are using for a positive (deficient) control for factor XIII assay by the clot-lysis methodology. Deficient plasma?
Hello, Kaarin, thanks for your question, which will attract some responses soon. A quick check of major plasma control distributors shows that only Hyphen BioMed, distributed in North America by Aniara, provides a factor XIII deficient plasma. We’ve also had some past discussion on factor XIII assays, linked here. I wonder how many of us continue to use urea solubility as our primary assay?
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We use the thrombin/acetic acid methodology for factor XIII
We use the thrombin/acetic acid methodology for factor XIII screen with no added Ca++. We do not rerun the assay, the reference lab does if required. With this technique we use EDTA plasma as our positive control, as there is no Ca++ available for XIII X-linking.
Hello, Kaarin and Crystal. Precision BioLogic Inc does provi
Hello, Kaarin and Crystal. Precision BioLogic Inc does provide a factor XIII-deficient control. Their CryoChek controls are assayed for factor XIII levels.
Hi there,
We are still performing the monochloroacetic acid
Hi there,
We are still performing the monochloroacetic acid solubility testing, using George King’s Factor XIII deficient plasma.