Aug 1 2025

george

Thrombotic Thrombocytopenic Purpura

Click “In Their Blood” for a review article about TTP from the University of Kansas (KU) Medical Center’s Pathology Department. The article highlights the early research into ADAMTS13‘s role in VWF metabolism, the early successes of PLEX therapy, and the current availability of the therapeutics caplacizumab and the ADAMTS13 concentrate, Adzynma. Also featured is the […]

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Bleeding Disorders

Jul 30 2025

george

August 2025 Cheat Sheet

Click here to see your August 2025 Fritsma Factor Cheat Sheet 8-1-25. If you would like your Cheat Sheet copy to arrive by email, please join the list using the invitation on the right. The Cheat Sheets, as well as all Fritsma Factor entries, are free, thanks to Precision BioLogic’s faithful sponsorship.

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Cheat Sheets

Jul 30 2025

george

August 2025 QQ: Anticoagulant Choice for AFIB

Our August 2025 Quick Question asks, “What AC does your provider prescribe for non-valvular AFIB?” I (Geo) asked my PCP this question at my annual wellness visit on July 29, 2025. Not a personal concern, just curious. Please provide your answer on the right and add your comments, which will appear in our end-of-month summary.

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Quick Question Archive

Jul 29 2025

george

July 2025 QQ: Hemophilia Rebalancing Therapy

Our July 2025 Quick Question asked, “Which is a hemophilia ‘rebalancing’ therapeutic?” The question attracted a modest 22 participants, perhaps an indication that rebalancing therapy was only FDA-approved in 2025 and awaits approval in Canada and Europe. Here are your responses… Valoctocogene roxaparvovec-rvox (ROCTAVIAN) 3 (14%) Efanesoctocog alfa (ALTUVIIIO) 1 (4%) Emicizumab (HemLibra) 7 (32%) […]

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Quick Question Archive

Jul 26 2025

george

Status of Gene-based Hemophilia A and B Therapy

Click here for an open-access, in-depth, illustrated review of the worldwide status of gene-based HA and HB therapy: Glasner MF, Pipe S, Miesbach W. Gene-based therapies for hemophilia. Res Pract Thromb Haemost. 2025;9:102870. doi: 10.1016/j.rpth.2025.102870. PMID: 40488175; PMCID: PMC12143782.

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Bleeding Disorders

Jul 23 2025

george

Anti-Xa DOAC Assay Variability

Click here to read an open-access article describing the variability in assay methodology when monitoring apixaban and rivaroxaban: Baker RM, Selby R, Moffat KA, St John M, Spyropoulos AC, Schulman S, Douketis J. Investigating interassay variability between direct oral anticoagulant calibrated anti-factor Xa assays: a substudy of the perioperative anticoagulation use for surgery evaluation (PAUSE) […]

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Anticoagulant Therapy

Jul 22 2025

george

Autoimmune Acquired Coagulation Factor Deficiencies

Click here for the open-access review of Ichinose A, Osaki T, Souri M. Diagnosis and treatment of autoimmune acquired coagulation factor deficiencies: an evidence-based review of Japanese practice. Semin Thromb Hemost. 2025;51:491-505. doi: 10.1055/s-0044-1787188. Epub 2024 Jun 12. PMID: 38866039. Abstract Among the acquired coagulation factor deficiencies, autoimmune coagulation factor deficiencies (AiCFD) are rare and […]

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Bleeding Disorders

Jul 22 2025

george

Postpartum DIC

Check with your medical library for this review, dated 7-18-25. Wolfovitz A, Brenner B, Solt I. Postpartum disseminated intravascular coagulation: A comprehensive review of pathophysiology, diagnosis, management, and prevention. Semin Thromb Hemost. doi: 10.1055/a-2645-2845. Epub ahead of print. PMID: 40680793. Abstract Disseminated intravascular coagulation (DIC) in the postpartum period is a rare but potentially life-threatening […]

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Fibrinolysis

Jul 15 2025

george

Genetic Study on VWD Variants

Click the JTH May issue abstract link: Friedman RK, Heath AS, Huffman JE, et al; National Heart, Lung and Blood Institute (NHLBI) Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Hematology & Hemostasis Working Group; VA Million Veteran Program; Blangero J, Fornage M, Kooperberg C, et al. Genetic study of von Willebrand factor antigen levels ≤ […]

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Bleeding Disorders

Jul 2 2025

george

What is Monoclonal Gammopathy of Thrombotic Significance?

Just when we thought there was nothing new in hemostasis, the June 2025 CAP Today front-page article by Karen Titus, Spectrum of Anti-PF4 Disorders Widens, ties together HITT, VITT, and what we have known as commonplace MGUS, here renamed MGTS, all fit together in the category, anti-PF4 disorders. I (Geo) recommend this excellent article that […]

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Thrombophilia