Bleeding Disorders

June, 2023 Quick Question Review

Our June 2023 Quick Question asked, “Name the bispecific antibody-based FVIII inhibitor bypass agent.” Our 68 respondents answered… Caplacizumab [Cablivi]: 3 [4%] Eculizumab [Soliris]: 8 [12%] Emicizumab [Hemlibra]: 53 [78%] Eloctate: 3 [4%] Jivi: 1 [2%] Genentech’s emicizumab is the bispecific antibody that bypassed FVIII in to join FIX to FX, activating FX. Emicizumab is […]

Quick Question Archive

Mother and Daughter With Hematomas

George, My daughter and I seem to have a tendency to bruise easily. She just got a big bruise the other day from a surfing accident and that episode started the conversation of why we bruise. I wonder if it could be a genetic possibility. We also are both blood type O and “23 and […]

Bleeding Disorders

New Educational Module: TMAs

Announcing our 35-minute educational module, Thrombotic Microangiopathies, or TMAs, also known as TTP, STEC-HUS, aHUS, ADAMTS13, VWF, MAHA, TMA, PLEX, and HELLP, what does it all mean? We hope you will find this helpful.

Bleeding Disorders

June 2023 Quick Question: Factor VIII Inhibitor Bypass

Our June Quick Question asks, “Name the bispecific antibody-based FVIII inhibitor bypass agent,” and lists several recently released therapeutics that are changing the shape of hemostasis disorder treatment. Please select your answer from the column on the right and add your comments below.

Quick Question Archive

April 2023 Quick Question: Prince Alexis

Our April 2023 Quick Question asked, “What was Russian Prince Alexis’s disorder? Our 41 participants chose: Hemophilia A [FVIII deficiency] 16 [39%] Hemophilia B [FIX deficiency] 15 [37%] Hemophilia C [FXI deficiency] 3 [7 %] Unknown 7 [17%] While the bodies of the Tsar, Tsarina, three daughters, and servants were exhumed in 1991, the remains […]

Bleeding Disorders

Concizumab: Anti-TFPI

On 4-17-2023, Novo Nordisk announced Health Canada’s approval of Alhemo®, their trademark for injectable concizumab, the first anti-tissue factor pathway inhibitor [TFPI] designed to prevent bleeds in Hemophilia A and B patients with inhibitors. The current Canadian approval supports relatively few Hemophilia B [Christmas disease] patients with inhibitors but generalization to Hemophilia A patients could […]

Bleeding Disorders

World Hemophilia Day April 17, 2023

Click here for the World Federation of Hemophilia on April 17, 2023, World Hemophilia Day. The theme this year is “Access for All: Prevention of bleeds as the global standard of care.” The call to action is to come together and advocate with local policymakers and governments for improved access to treatment and care with […]

Bleeding Disorders

March 2023 CAP Today: Over-transfusion

The March 2023 Issue of CAP Today offers an anecdotal study on over-transfusion. The data could be enhanced with a review of laboratory assays such as viscoelastometry that help direct the need for red cells, platelets, or component-based hemostasis control. If you have experience with coag-based transfusion monitoring, please comment.

Bleeding Disorders

Webinar: The Many Faces of VWF Part 1: Von Willebrand Factor and Acquired von Willebrand Syndrome

Fritsma Factor participants, we invite you to view Part 1 of our video: series ‘Coag Conversations’ The Many Faces of von Willebrand Factor; or Von Willebrand Factor, ADAMTS13, Malignancy, and Beyond: Von Willebrand Factor and Acquired von Willebrand syndrome, A Kaleidoscope of Presentations.” This is the first of a three-part series sponsored by BioMedica Diagnostics of […]

Arterial Thrombosis

February, 2023 Quick Question: VWF Activity Assays

Our February 2023 Quick Question, “What VWF activity assay do you use?” attracted 32 responses. Here are the results: Automated VWF:RCo: 12 [38%] VWF:RCo: 10 [31%] VWF:GP1bR: 3 [9%] VWF:GP 1bM: 4 [13%] VWF:Ab: 2 [6%] VWF:CB: 1 [3%] Although the aggregometer-based ristocetin cofactor activity assay [VWF:RCo] is criticized for poor reproducibility, with interassay CV […]

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

Cheat Sheets from George

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