HemLibra

I’ve attached an article from the September, 2018 issue of CAP Today describing the efficacy of emicizumab, Genentech’s synthetic “bispecific” antibody designed to bypass factor VIII inhibitor in hemophilic boys. The article illustrates how emicizumab (HemLibra) is turning hemophilia therapy upside down. Yesterday, October 5, 2018, HemLibra was additionally approved for all hemophilia A sufferers, […]

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Bleeding Disorders

Sep 11 2018

george

East Texas Bleeding Disorder

Here is a fascinating response to our September 2 solution to the August 10 Minimally Prolonged PT discussion, from Dimitrios Liapis MSc, Vascular Research Private Medical Center, Athens, Greece. From Mr. Liapis: A very interesting case! Did the patient or members of the immediate family report any bleeding history? Other coagulation tests besides PT? It […]

Bleeding Disorders

Minimally Prolonged PT: Solution

Referring to our post of August 10, 2018 entitled Minimally Prolonged PT, Dr. Laposata reviewed the patient’s consistently, though slightly prolonged, PT results, and considered a factor VII deficiency. It turns out the patient’s factor VII level was 40%, found also in some first-degree relatives. It may not be that a factor VII level of […]

Bleeding Disorders

Reference Intervals

I recently became reacquainted with colleague Madeline Ducate, PhD, who supports pharmaceutical houses with the laboratory needs for international clinical trials. Madeline is occasionally confronted with a lack of laboratory reference intervals in under-resourced countries, where cultural norms or the lack of funding limit specimen collection and processing from healthy subjects. In vitro diagnostics companies […]

Bleeding Disorders

HGB Variations During the Day

George, periodically we see patients that have a gram or so difference in their hemoglobin levels which causes some duress with the clinicians. Recently we had a nursing home patient (s/p hip fracture repair) who had a venous draw early in the morning that was sent to our in house hospital laboratory and resulted in […]

Bleeding Disorders

July, 2018 Quick Question: Factor IX Assay Method

Here are the results of our July, 2018 Quick Question, “How do you measure factor IX therapy?” Clot-based factor assay (34) 83% Immunoassay (4) 10% Chromogenic substrate (3) 7% We had 41 respondents. Although there are a few chromogenic substrate-based factor IX assays available worldwide, none has been approved by the US FDA, though two […]

Bleeding Disorders

Chromogenic Modified Nijmegen-Bethesda Assay

We’ve attached a news release announcing Precision BioLogic’s latest poster, presented at the 2018 International Society on Thrombosis and Haemostasis Scientific Subcommittees meeting in Dublin. Please tap or click on the link below for the release and a copy of the poster. Chromogenic Modified Nijmegen-Bethesda Assay News Release Chromogenic Modified Nijmegen-Bethesda Assay Poster

Bleeding Disorders

VWD Diagnosis and Management Survey

Thanks to Elaine Benoit, Precision BioLogic, for referring the following survey, also found on LinkedIn. As recently announced, the ISTH is collaborating with ASH, NHF and WFH to create clinical practice guidelines for the diagnosis and management of von Willebrand Disease (VWD). In the initial phase of development, a stakeholder survey has been created to […]

Bleeding Disorders

July Quick Question: Factor IX Assay

Please refer to our July, 2018 Quick Question, which looks a lot like our June question about factor VIII assays. The new question asks about your approach to factor IX assays, and relates to concerns for accuracy when measuring the extended half-life factor IX concentrates.

Bleeding Disorders

Quick Question: Factor VIII Assay

Here are the unsurprising resuts of our June, 2018 Quick Question, “How do you measure factor VIII therapy?” Clot-based factor assay: 82% (36) Immunoassay: 5% (2) Chromogenic substrate: 14% (6) Dave McGlasson suggested this question because our current clot-based methods are unreliable when assaying for synthetic B-domain deleted and extended half-life preparations, many of which […]

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Bleeding Disorders

Bleeding Disorders

HemLibra

East Texas Bleeding Disorder

Minimally Prolonged PT: Solution

Reference Intervals

HGB Variations During the Day

July, 2018 Quick Question: Factor IX Assay Method

Chromogenic Modified Nijmegen-Bethesda Assay

VWD Diagnosis and Management Survey

July Quick Question: Factor IX Assay

Quick Question: Factor VIII Assay

George Fritsma MS MLS

Cheat Sheets from George

Questions or Comments?

Quick Question