Here is a short free full text article describing the outcomes of the 2010–17 Survey of Inhibitors in Plasma-Product Exposed Toddlers (SIPPET) study. The study compares inhibitor incidence arising from rFVIII (recombinant) concentrate compared to pdFVIII (plasma-derived) concentrate. Further, in an important addition to hemophilia therapy protocol, SIPPET also compares inhibitor incidence in hemophilic F8 null versus non-null genotypes.
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