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More on Specimen Storage

Frequent contributor and coag expert Dave McGlasson sent this linked scanned copy of a 1985 article in his state newsletter, “The Texan.” The article documents factor VIII deterioration when stored at –20°C. This is a follow-up to our June 15, 2023 post, Freezing Coagulation Specimens.

Coagulation Factors

Coag Conversation Part 3: VWF and ADAMTS13: Cardiovascular Diseases

Introducing The Many Faces of von Willebrand Factor or, von Willebrand Factor, ADAMTS13, Malignancy and Beyond Part 3: von Willebrand Factor and ADAMTS13; Thrombotic Mechanisms and Cardiovascular Diseases. This 30″ talk features George A. Fritsma, MS, MLS, proprietor of The Fritsma Factor, Your Interactive Hemostasis Resource, and Emmanual Favaloro, PhD, Principal Hospital Scientist at the […]

Arterial Thrombosis

Freezing Coagulation Specimens

Yesterday, June 14, 2023, I [Geo] received two questions about coagulation plasma specimen management. Heather DeVries, Indiana University, asked if there were data supporting the CLSI two-week maximum for storing plasma frozen at –20°C, and Jessica Warner, Kettering Health, asked how soon after thawing you must run an assay. The CLSI guideline H21-A5, Clinical and […]

Specimen Management

New Educational Module: TMAs

Announcing our 35-minute educational module, Thrombotic Microangiopathies, or TMAs, also known as TTP, STEC-HUS, aHUS, ADAMTS13, VWF, MAHA, TMA, PLEX, and HELLP, what does it all mean? We hope you will find this helpful.

Bleeding Disorders

Precision BioLogic Poster at ISTH: DOAC-Remove

You are invited to visit the ISTH poster submitted by Precision BioLogic Inc.: PB1147 Effect of high-dose direct anticoagulant drugs and DOAC-Remove on lupus anticoagulant detection by a hexagonal phase phospholipid assay. The poster goes up Tuesday, 27 June 2023, 18:30–19:30.

Specimen Management

CLN: Viscoelastometry Article

Here is a May 2023 Clinical Laboratory News cover review by colleague and fellow “clotter” Oksana Volod, MD, entitled “Is TEG the Right Assay? [click]” The article describes the updated means for near-patient viscoelastometry assays, whose original methodology became available in 1948. Clinical Laboratory News is a widely distributed American Association for Clinical Chemistry [AACC} […]

Global Hemostasis Assays

Familial APS?

On June 1 a Fritsma Factor participant asked if there were any evidence of a familial prevalence for symptomatic antiphospholipid syndrome [APS] or lab evidence for the familial distribution of one of the antiphospholipid antibodies [APAs]: lupus anticoagulant [LA], anti-cardiolipin antibody [ACA], or anti-beta-2-glycoprotein 1. I [Geo] located only a single case report: Bhattacharya S, […]

Lupus Anticoagulant

June 2023 Cheat Sheet

Here is a copy of your June 2023 cheat sheet. Your personal copy will arrive by email in a few days.

June 2023 Quick Question: Factor VIII Inhibitor Bypass

Our June Quick Question asks, “Name the bispecific antibody-based FVIII inhibitor bypass agent,” and lists several recently released therapeutics that are changing the shape of hemostasis disorder treatment. Please select your answer from the column on the right and add your comments below.

Quick Question Archive

May 2023 Quick Question: DTI

Our May 2023 Quick Question asks, “Which DOAC is a direct thrombin inhibitor? Our 70 respondents chose… Dabigatran [Pradaxa]: 56 [80%] Rivaroxaban [Xarelto]: 3 [4%] Apixaban [Eliquis]: 3 [4%] Warfarin [Coumadin]: 7 [10%] Clopidogrel [Plavix]: [2%] Dabigatran is the direct thrombin inhibitor, whereas rivaroxaban and apixaban are direct anti-Xa inhibitors. Clopidogrel is an antiplatelet antithrombotic. […]

Quick Question Archive

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

Cheat Sheets from George

Quick Question