On June 1 a Fritsma Factor participant asked if there were any evidence of a familial prevalence for symptomatic antiphospholipid syndrome [APS] or lab evidence for the familial distribution of one of the antiphospholipid antibodies [APAs]: lupus anticoagulant [LA], anti-cardiolipin antibody [ACA], or anti-beta-2-glycoprotein 1. I [Geo] located only a single case report:
However, on June 4, fellow “clotter” Dave McGlasson provided his 1992 abstract, “Berdeaux DH, McGlasson DL, Marlar RA. Familial Association of Antiphospholipid Antibodies in Index Patients with Primary Antiphospholipid Syndrome. Clin Exp Rheumatology, Vol 10/6, pg. 655, Nov/Dec 1992, [click].
Additionally, our mutual colleague Daniel Kaczor commented, “Hi George, Hope you are well. I am responding to the Familial APS issue. Although I can’t think of a published reference I can tell you that I indeed identified a family [mother/father and 3 children including an infant] who were all APA positive and LA negative. The testing was done in my lab when I was at Lehigh Valley Hospital. I can’t remember which experienced the thrombotic episode but that was why we did the testing. Keep up the good work! Regards, Dan Kaczor