From Debbie Moffitt in Honolulu:
Someone brought up a question regarding platelet testing with the PFA-100. As far as I know, we are concerned about prolonged results, but is a result less than the normal range normal or abnormal? Should we be concerned about a hypercoagulable state? What would be the appropriate action? Would we ask for a redraw or what kind of comment
should be made with the results, if reported?
Deborah Moffitt MT (ASCP)
Diagnostic Laboratory Services
Queens Medical Center
Hi, Debbie, and thank you for your question. Have you seen a number of shortened PFA-100 results, or is this more a hypothetical question? Actually, I know of no significance for shortened PFA results, none have ever been correlated with platelet hyperaggregability or thrombophilia, though the possibility is intriguing. There are several publications, many by the late Dr. E Mammen of Wayne State University, Detroit, that define platelet hyperaggregability as an aggregation response to reduced ADP or epinephrine agonist concentrations. These have been correlated to a number of arterial thrombotic events, although mostly by individual case study historical review. In none of these have I seen the PFA-100 compared to aggregation results, however.