Post-Orthopedic Surgery Anticoagulation

Click here to receive the open-access review article, Sarkar MK, Laposata M. Is aspirin the best choice today for prophylaxis against venous thromboembolism after orthopedic surgery? Tex Ortho J 2017:3; 45–54 DOI: 10.18600/toj.030407. Sarkar and Laposata reviewed various agency guidelines for all AC therapy over the past several years and provided the current recommendations.

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Anticoagulant Therapy

Sep 2 2025

george

September 2025 Cheat Sheet

Click here to see your 2025 Fritsma Factor Cheat Sheet: Cheat Sheet 9-1-25. To receive your own Cheat Sheet via email “push,” see the right-hand column of the “Posts’ page and sign up. The Cheat Sheet and Fritsma Factor are free. We are sponsored by Precision BioLogic Inc.

Cheat Sheets

Quality Management in a Hemostasis Laboratory

Here’s an open-access August 2025 article, Sarkar MK, Quality management in a hemostasis laboratory. This article is an excellent companion to our August 29, 2025 post, Hemostasis Assay Statistical Variability. The August post referenced my colleague and friend, Dr. Mayukh Sarkar, who narrated our Hemostasis Quality Control units that are linked in the August post […]

Validation

September 2025 QQ: Viscoelastometry

Our September 2025 QQ is a poll that asks, “What viscoelastometry device is employed at your facility?” Often, VET devices are employed in the OR or ER, both near-patient applications. For many years, we’ve used the time-honored Thromboelastograph (TEG) 5000 or its competitor, the Sonoclot, both of which are available worldwide. Newer offerings include the […]

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Quick Question Archive

Sep 1 2025

george

August 2025 QQ: Direct Oral Anticoagulants

Our August 2025 QQ is a poll that asked, “What AC does your provider prescribe for non-valvular AFIB?” Here are the choices made by our 18 responders: Apixaban (Eliquis) 10 (56%) Clopidogrel (Plavix) 0 Dabigatran (Pradaxa) 3 (16%) Rivaroxaban (Xarelto) 1 (6%) Warfarin (Coumadin) 4 (22%) This QQ arose from discussions with my (Geo) PCP […]

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Anticoagulant Therapy

Aug 30 2025

george

NXT007: A First-in-human Study of a Factor Bypassing Hemophilia Therapy

Check with your medical library for a copy of Sambe T, Miwa T, Yoneyama K, et al. A first-in-human study of NXT007, a next-generation, activated factor VIII-mimetic bispecific antibody, in healthy participants. J Thromb Haemost. 2025: S1538–7836(25)00399-X. doi: 10.1016/j.jtha.2025.06.013. PMID: 40554054. Here’s the abstract: Background: NXT007 is a bispecific antibody that mimics the cofactor function […]

Bleeding Disorders

Hemostasis Assay Statistical Variability

Here is an open-access commentary that addresses concerns about hemostasis assay statistical variability as it relates to clinical significance. Click: Mullier F, Gouin-Thibault I, Meijer P, et al. Time to integrate measurement uncertainty in method comparison and interpretation of hemostasis laboratory assays. Res Practice Thromb Hemost 2025: 9, https://doi.org/10.1016/j.rpth.2025.102993. For a two-part discussion about hemostasis quality assurance […]

Validation

Charcoal Adsorbents Remove Anti-FXIa Interference

My (Geo) audio PowerPoint, Managing Direct Oral Anticoagulants, was posted in 2021. One of the final slides indicates experimental anticoagulant formulations designed to suppress FXI activation, aiming to reduce thrombotic risk without increasing the risk of bleeding. Click open-access article Buckley GT, Crowley MP, Harte JV. Interferences associated with the factor XIa inhibitors asundexian and […]

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Anticoagulant Therapy

Aug 27 2025

george

World Thrombosis Day Campaign: Note From Samantha Nelson, WTD Manager

Dear George, The International Society on Thrombosis and Haemostasis (ISTH) World Thrombosis Day (WTD) campaign is in its 12th year, and together with The Fritsma Factor, Your Interactive Hemostasis Resource, we have been working to build awareness around a critical reality: 1 in 4 people worldwide die each year from conditions related to thrombosis. This […]

Thrombophilia

More On Anti-Xa DOAC Variability

Click our 7-23-25 entry, Anti-Xa DOAC Variability for an 8-21-25 reference from Dr. Emmanuel Favaloro.

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Anticoagulant Therapy

All Posts

Post-Orthopedic Surgery Anticoagulation

September 2025 Cheat Sheet

Quality Management in a Hemostasis Laboratory

September 2025 QQ: Viscoelastometry

August 2025 QQ: Direct Oral Anticoagulants

NXT007: A First-in-human Study of a Factor Bypassing Hemophilia Therapy

Hemostasis Assay Statistical Variability

Charcoal Adsorbents Remove Anti-FXIa Interference

World Thrombosis Day Campaign: Note From Samantha Nelson, WTD Manager

More On Anti-Xa DOAC Variability

George Fritsma MS MLS

Cheat Sheets from George

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