Larry Brace, PhD, Edward Hospital, Naperville, IL. writes that a pathologist is building a protocol to employ platelet concentrate transfusions for reversal of platelet inhibition for patients who are on Plavix or aspirin and are having bleeding or need surgery. He is looking for an objective way to quickly evaluate the status of the platelet population after transfusion. Dr. Brace is looking for any information about suitable lab testing. The aggregation-based P2Y12 inhibition assay for Plavix is a measurement designed to see if the Plavix is working to inhibit function, not to learn if the platelets are properly working, Same for VerifyNow for aspirin, to determine if aspirin is inhibiting function, not to see if platelets are overall working properly. The Siemens PFA100 might be the answer, but would require some literature confirmation. How would you respond? Thanks,
George suggested using thromboelastometry or thromboelastography, but would like to leanr our participants’ suggestions.