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Quick Question: Mixing Studies

Here are the results from our July Quick Question:

When do you perform partial thromboplastin time (PTT) mixing studies?

a.  Any non-heparin PTT that is prolonged beyond the upper limit of normal: 43%
b. Any non-heparin PTT that is substantially prolonged beyond the upper limit of normal: 15%
c.  We solicit clinical information before performing mixing studies: 28%
d.  We don’t perform mixing studies: 9%
e.  Please e-mail George if you have other comments: 5% (These appear as blog posts)

These results seem reasonable, but I would like to reiterate a comment I heard from Dr. Dorothy (Dot) Adcock-Funk at the Midwest Hemostasis conference in May, 2010 that there is little to be gained from performing mixing studies on a specimen that is prolonged just a second or two beyond the upper limit of the reference interval.

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