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Prothrombinase-Induced Clotting Test

I need your help. I have only a brief acquaintance with CenterChem’s Pefakit prothrombinase-induced clotting test (PiCT). Samama MM, Guinet C, Laboratory assessment of new anticoagulants. Clin Chem Lab Med 2011;49:761–72 supports the PiCT for monitoring fondaparinux, dabigatran, and rivaroxaban (with minor modifications). The PiCT has been available for at least ten years for monitoring standard unfractionated heparin and low molecular weight heparin. I’m presenting a talk in June on monitoring the new anticoagulants. Do you have experience with the PiCT? If so, could you tell me how it works and how effective it is? I’ll give attribution in my presentation, thank you! Geo.

Comments (1)
Jul 14, 2011 4:16am

Hi Geo.

I’m sorry that I came this late in commenting. In
Hi Geo.

I’m sorry that I came this late in commenting. In case you might still be interested in learning more about PiCT I would love to share some information with you. At Pentapharm we are currently developing a new version of PiCT delivering results in seconds instead of units. So far it is showing great performance with UFH, LMWH, Hirudin and even synthetic peptidic anti-Xa inhibitors. We are next looking at dabigatran, rivaroxaban and fondaparinux. Absolute numbers in seconds between different analyzers, optical or mechanical, are remarkably comparable. I could refer you to one of the key users in Europe for an independent opinion if interested. Abel (R&D Manager @Pentapharm)

Hello and thanks, Abel. You are not late with your comment, rather you are timely. I’d like to meet you and learn more about PiCT, will you be attending either the Mayo Labs meeting, August 4 and 5, or the Esoterix meeting, September 8 and 9? Geo.

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