High-sensitivity D-dimer?

Sep 27, 2019 12:42pm

A colleague has seen references to a "High-sensitivity" D-dimer assay. George answered he's not heard of this, perhaps it is just a synonym for a standard D-dimer assay. If you have any experience with this, please respond to george@fritsmafactor.com or comment below.

Fibrinolysis

3 Comments

By Scientist In Charge- Coagulation Robyn Coleman

Oct 3, 2019 12:49am

Hi , in general terms, manufacturers use this term to promote their version of D-dimer having a higher sensitivity for VTE/PE prediction. The automated lab based LIA versions compared to the POC versions with lower sensitivity. Robyn

By Dr Paul Riley

Dec 16, 2019 3:44pm

My understanding is that all automated / immunoturbidimetric and POC D-dimer assays are considered "high sensitivity." The "high sensitivity" terminology is used to distinguish quantitative D-dimer assays from whole blood and/or qualitative card assays which had been used before the advent of the automated and POC assays. See Di Nisio M et al. Diagnostic accuracy of D-dimer test for exclusion of VTE: a systematic review. JTH 2006;5:296-304.

By Rodel

Dec 18, 2019 12:48pm

The high sensitive D-dimwe that I was exposed to is the ELISA method by an instrument called VIDAS. This is the gold standard method compared to latex method by manual or automated. Rodel

High-sensitivity D-dimer?

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