Genetic Study on VWD Variants

Click the JTH May issue abstract link: Friedman RK, Heath AS, Huffman JE, et al; National Heart, Lung and Blood Institute (NHLBI) Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Hematology & Hemostasis Working Group; VA Million Veteran Program; Blangero J, Fornage M, Kooperberg C, et al. Genetic study of von Willebrand factor antigen levels ≤ […]

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Bleeding Disorders

Jul 2 2025

george

What is Monoclonal Gammopathy of Thrombotic Significance?

Just when we thought there was nothing new in hemostasis, the June 2025 CAP Today front-page article by Karen Titus, Spectrum of Anti-PF4 Disorders Widens, ties together HITT, VITT, and what we have known as commonplace MGUS, here renamed MGTS, all fit together in the category, anti-PF4 disorders. I (Geo) recommend this excellent article that […]

Thrombophilia

Poster: Monitoring FVIII in Hemophilia Patients Treated with Bypassing Therapeutics

To review the PBI poster presented at the 2025 ISTH meeting, click Effect of Mim8 and Emicizumab on Factor VIII Recovery by a Novel, Bovine Chromogenic FVIII Assay. Tara Quinton, Meghan Bruhm, Karen M. Black, Ali Sadeghi-Khomami. Precision BioLogic Inc., Dartmouth, Nova Scotia, Canada. The poster illustrates the validity of bovine reagent-based chromogenic substrate FVIII […]

Bleeding Disorders

July 2025 Cheat Sheet

Click here for your July 2025 Cheat Sheet. Also, watch for your “push” version that will hit your mailbox in a few days. If you would like to receive your copy via email, provide your contact information in the right-hand column. Fritsma Factor participation is free, and your comments are welcome.

Cheat Sheets

July 2025 Quick Question: Hemophilia Therapeutics

At the June 21–25 ISTH meeting in Washington, DC, we heard several quality presentations describing the new hemophilia treatment materials, including updated EHL concentrates plus the bypassing, rebalancing, and gene transfer therapies. In follow-up, our July 2025 Quick Question asks you to select the choice that represents the recently approved rebalancing therapies. Please make your […]

Bleeding Disorders

June 2025 Quick Question Summary: Fibrinolysis

Our June 2025 Quick Question was a quiz that asked, “Which fibrinolysis component directly digests fibrin?” Our 51 respondents answered… Plasminogen: 12 (23%) Antiplasmin: 0 D-dimer: 1 (2%) Plasmin: 37 (73%) TPA: 1 (2%) The correct answer is #4, plasmin. In brief, plasminogen is a zymogen. Plasmin, the activated form of plasminogen, binds and digests […]

Fibrinolysis

Differential Discussion: Hemophilia Part 2

On June 6, 2025, Malissa Norfolk and Dave Cabral posted George’s audio PowerPoint, “Have We Cured Hemophilia, Part 1?.” On June 25, Malissa and Dave posted “Have We Cured Hemophilia, Part 2?” Each video is 30″ long. Please feel free to watch and comment below.

Bleeding Disorders

DIC Update

On Monday, June 23, Ecaterina (Katy) Scarlatescu, MD, PhD, Department of Anaesthesia and Intensive Care, Fundeni Clinical Institute, University of Medicine and Pharmacy, Bucharest, Romania, chaired a plenary session of panelists at the ISTH annual meeting in Washington, DC, USA. The panel discussed the 2025 ISTH DIC definition and diagnostic guidelines we reported on June […]

Thrombophilia

Invent-VTE

In the ISTH annual meeting (June 21–25, 2025) I (Geo) met a representative of Invent-VTE, a non-profit dedicated to fostering international VTE research collaboration. Navigate to Hemostasis Agencies to see Invent-VTE‘s website and our complete list of hemostasis-related agencies.

Events

Lab Assessment of FVIII Inhibitors

Click here for an open-access article describing the need for factor inhibitor assessment: Favaloro EJ, Curnow J, Pasalic L. Laboratory assessment of factor VIII inhibitors: when is it required? A perspective informed by local practice. J Clin Med. 2024;14:13. doi: 10.3390/jcm14010013. PMID: 39797095; PMCID: PMC11720995. See also our factor inhibitor discussions under the Bleeding Disorders heading.

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Bleeding Disorders

All Posts

Genetic Study on VWD Variants

What is Monoclonal Gammopathy of Thrombotic Significance?

Poster: Monitoring FVIII in Hemophilia Patients Treated with Bypassing Therapeutics

July 2025 Cheat Sheet

July 2025 Quick Question: Hemophilia Therapeutics

June 2025 Quick Question Summary: Fibrinolysis

Differential Discussion: Hemophilia Part 2

DIC Update

Invent-VTE

Lab Assessment of FVIII Inhibitors

George Fritsma MS MLS

Cheat Sheets from George

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Quick Question