We are getting a lot of questions about monitoring Pradaxa (dabigatran) and it keeps coming back to the Ecarin clotting time (ECT). Do you know of any POC testing kit or instrument that could be used to monitor this drug’s effect on a patient’s clotting?
Teresa Black, MT(ASCP)
Senior Medical Technologist
Orlando Regional Medical Center
Hi, Terry, and thank you for your question. Here is a link to a message from Judy Miller posted on November 24 describing Hyphen Biomed’s new Thrombin Inhibitorassay for direct thrombin inhibitors, which Hyphen claims is linear for dabigatran measurement. They also report that prothrombin time, partial thromboplastin time, and Ecarin time are not linear.
I know of no point of care instrument available for dabigatran monitoring just now, and speculate that maybe one of the prothrombin time point of care instruments could be modified to monitor dabigatran as the market grows. Does anyone know of a point of care procedure?