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Platelet Function Testing

From Ahmed Siddig Akasha: Please inform me about simple procedure of platelet aggregation test, the principle, procedure, and results interpretation and the normal values. Thank you.

Hello, and thank you for your question, which provides me the opportunity to highlight our audio PowerPoint educational modules. You will find the information you request in modules 29–34, and especially modules 32, 33, and 34, Platelet Function Testing Parts 1–3. Each module requires approximately 30 minutes to complete, and you may earn continuing education credit for each.

By way of summary, you test for platelet function using platelet aggregometry, in which whole blood or platelet rich plasma is pipetted to a cuvette, an agonist is added, and platelet response is measured by impedance or light transmission over a period of 6–10 minutes. Impedance aggregometry also adds a luminescence channel that records platelet secretion in addition to platelet aggregation. The results from platelet response to each agonist are recorded as a tracing and compared to normal platelet responses. A number of platelet abnormalities, including response to antiplatelet drugs, platelet membrane disorders, platelet secretion disorders, and storage pool deficiency are diagnosed in this method.

The Siemens PFA-100 is a point of care instrument that may be used to detect platelet function disorders, and the Accriva VerifyNow instrument or its competitor, the Roche Multiplate analyzer detects platelet response to aspirin, thienopyridine drugs, and glycoprotein IIb/IIIa inhibitors. Helena PlateletWorks is another simple means to detect platelet function.

The audio PowerPoint modules provide specifics of methodology, normal results, assay limitations, and clinical interpretation. I hope this is helpful to you, and if you have any additional questions, please feel free to respond below.

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