From Kathy Jacobs at Chronolog, Inc.
Hi George, When a patient’s platelets clump in sodium citrate, is there another anticoagulant that can be used to allow LTA platelet aggregation testing? Thanx in advance, Kathy.
Hi, Kathy, good to “hear” from you. You posted your question originally as a comment to a 2007 post, so I decided to bring it to the top to ensure everyone sees it. On two occasions I’ve used heparinized specimens for CBCs when EDTA and citrate specimens exhibited clumping and satellitosis, however, I doubt this would work for light transmittance (LTA) or for impedance aggregometry. I’m guessing your client has probably already tried heparin, anyway. I’ve heard of people mildly vortexing a sample with slight clumping, but, again, that probably would just activate or destroy the platelets. Beyond that, I don’t really have a solution, but let’s hope that one of our blog participants has come up with something. I’d be curious to learn about the patient’s condition, is it satellitosis, or hyperaggregable platelets? Geo