From Dr. David Floering:
Is anyone routinely using heparin anti-Xa assay to monitor heparin instead of PTT? If so, what are the experiences?
David Floering, MD
Medical Director, Pathology
Atrium Medical Center
Dr. Floering, thank you for your question. I have several acquaintances who have successfully converted from PTT to the chromogenic anti-Xa heparin assay for unfractionated heparin, low molecular weight heparin, and more recently, the synthetic pentasaccharide Fondaparinux. I’m forwarding your question to a few of them directly for comment. By hearsay, all have been quite happy with the better accuracy of the anti-Xa as it is unaffected by inflammation, raised factor levels, and inhibitors. I’ll await specifics from colleagues. Geo.