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Heme Binds Factor VIII

There is a thought-provoking article in the June, 2012 issue of Journal of Thrombosis and HaemostasisRepesse Y, Dimitrov JD, Peyron I, et al. Heme binds to factor VIII and inhibits its interaction with activated factor IX. J Thromb Haemostas 2012;10:1062–71. The authors do not speculate on in vitro specimen hemolysis, however their findings could provide additional support for rejecting hemolyzed specimens. Geo

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