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Aug 30 2025
george

NXT007: A First-in-human Study of a Factor Bypassing Hemophilia Therapy

Check with your medical library for a copy of  Sambe T, Miwa T, Yoneyama K, et al. A first-in-human study of NXT007, a next-generation, activated factor VIII-mimetic bispecific antibody, in healthy participants. J Thromb Haemost. 2025: S1538–7836(25)00399-X. doi: 10.1016/j.jtha.2025.06.013. PMID: 40554054. Here’s the abstract: Background: NXT007 is a bispecific antibody that mimics the cofactor function […]
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Bleeding Disorders
Aug 29 2025
george

Hemostasis Assay Statistical Variability

Here is an open-access commentary that addresses concerns about hemostasis assay statistical variability as it relates to clinical significance. Click: Mullier F, Gouin-Thibault I, Meijer P, et al. Time to integrate measurement uncertainty in method comparison and interpretation of hemostasis laboratory assays. Res Practice Thromb Hemost 2025: 9, https://doi.org/10.1016/j.rpth.2025.102993. For a two-part discussion about hemostasis quality assurance […]
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Validation
Aug 29 2025
george

Charcoal Adsorbents Remove Anti-FXIa Interference

My (Geo) audio PowerPoint, Managing Direct Oral Anticoagulants, was posted in 2021. One of the final slides indicates experimental anticoagulant formulations designed to suppress FXI activation, aiming to reduce thrombotic risk without increasing the risk of bleeding. Click open-access article Buckley GT, Crowley MP, Harte JV. Interferences associated with the factor XIa inhibitors asundexian and […]
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Anticoagulant Therapy
Aug 16 2025
george

July 2025 CAP Today: A Deep Dive Into Key Hemostasis Testing Variables

Click A Deep Dive Into Key Hemostasis Testing Variables for an in-depth review of preanalytical hemostasis specimen concerns. The CAP article features Andrew Goodwin MD, professor, Department of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, and medical director of the thrombosis and hemostasis section, University of Vermont Medical Center; and Dr. […]
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Specimen Management
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George Fritsma MS MLS

George Fritsma is a medical laboratory scientist, educator, and author. George  is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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What AC does your provider prescribe for non-valvular AFIB?