I attended your session on coagulation problems at the NW Medical Lab Symposium. Thank you for a great presentation and for putting the symposium information on your website.
I would like to know what protocol you use for checking out new lots of D-dimer reagent. We use the Siemens Stratus for D- dimer and they recommend a control by Innovance. There used to be product insert information about target QC ranges for each lot of reagent but they’ve stopped providing it.
We are a STAT lab in a clinic, so our patient volume is fairly low. We’ve been running 4 or 5 patients on the old and new lots of reagent and they generally agree well. We’re not sure how many QC data points we need to establish the new range and usually call Siemens to get peer data to set the range. Any recommendations you have would be appreciated.
Do I need to register on your website to receive an answer?
Thanks again for speaking at our meeting. I hope you enjoyed your visit.
Toni Okada, MLS, (ASCP), Lab Manager
Laboratory Services, Group Health Cooperative
Bellevue Medical Center
Hi, Toni, I am glad you were able to attend the Top Ten talk in Seattle (Lynnwood) and thank you for your compliment and your question. No, you don’t need to register on the site to receive your answer, however you may wish to register to append comments to recent posts and to receive our monthly cheat sheet.
I don’t have a satisfactory answer, though as you remember from the Top Ten presentation, there is a strong need for normalizing the D-dimer assay. I am surprised that the Innovance material no longer provides targets, and have contacted a Siemens representative for follow-up on the question. I checked with Cari Reed at UAB, and like many, UAB uses the controls provided in the kit, which automatically check calibration when placed on the instrument. We are using Diagnostica Stago’s materials. I’ve also checked with several plasma suppliers, and have not found a D-dimer calibration/QC control set. By posting the question, we may hear from someone who can provide some answers on lot-to-lot D-dimer management.