From Suakimi Pouhila, Auckland District Health Board, New Zealand. We have a patient which showed high D-dimer results with Siemens’ Innovance D-dimer but normal Stago D-dimer results. Has anyone seen this before? Is this due to cross reaction with a heterophile antibody?
Hello, Suakimi Pouhila, and thank you for your question. The various monoclonal antibodies that are employed in the D-dimer assays by manufacturers all have slightly different targets, thus there are often discrepancies among results, as illustrated by the variance in results of external quality assurance programs. However, the degree of discrepancy that you describe is unusual. I’ve contacted my US acquaintances at Siemens and Stago to learn if they have any insight.