Thrombophilia

VWF in Cardiac Disorders

In the Rutgers CLSD 5124 Advanced Hemostasis graduate course, a participant responded to the question, “Show how VWF and platelets appear to be involved in cardiac insufficiency and atrial fibrillation.” The question referred to our Coag Conversation with Dr. Emmanuel Favaloro, The Many Faces of VWF. The response: VWF is a glycoprotein heavily engaged in […]

Arterial Thrombosis

Readily Measurable Products of SARS-Cov-2 Endothelial Cell Injury

This is the second in a series of discussions about the relationship between hemostasis and inflammation. These discussions were part of our Rutgers CLSC 5124 Advanced Hemostasis course that features answers provided by our participants. List the readily measurable products of SARS-Cov-2 mediated endothelial cell injury. SARS-CoV-2 is increasingly being recognized as a disease of […]

Trauma-induced Coagulopathy Conversation Part 3

Part 3 of my Coag Conversation with Dr. Maureane Hoffman entitled Trauma-induced Coagulopathy; The Laboratory’s Role in Care, is now available from the BioMedica Diagnostics website.

Bleeding Disorders

FXII and Inflammation

This question was posted in the Rutgers graduate course, CLSC 5124 Advanced Hemostasis: Explain how FXII and FXI are activated by vascular assist devices and show their connection with inflammation. Here is an answer provided by one of the course participants: The contact pathway may be initiated by FXII binding to a negatively charged surface […]

Arterial Thrombosis

November 2023 QQ: Platelet Hyperaggregability

Our November Quick Question is another poll, this time in response to our provocative October 4, 2023 discussion, initiated by Dr. Mayukh Sarkar, entitled “Sticky Platelet Syndrome.” The question asks, “Do you test for platelet hyperaggregation?” As always, please answer the poll and then post your written opinion in the “Comments” section below.

Quick Question Archive

Sticky Platelet Syndrome

On 10-4-23 Mayukh Sarker, PhD asked, “At the October 4–6 Mayo conference someone asked. ‘what is sticky platelet syndrome, and can it be defined and diagnosed?’ The consensus was no, it was an “old school” thought but it currently can’t be diagnosed clinically or by the laboratory. What are your thoughts on this?” On 10-5-23 […]

DIC and Hemolysis

Anne D’ Agostino asks, “Should we reject hemolyzed samples from someone in DIC?” The simple answer is “do not reject,” because the hemolysis is likely intravascular, reflecting DIC‘s microangiopathic hemolytic anemia [MAHA]. But to elaborate, there’s no foolproof way to differentiate intravascular [in vivo] hemolysis from spurious [in vitro] hemolysis, the consequence of specimen collection […]

Bleeding Disorders

Poster: Effect of High-Dose DOACs and DOAC-Remove on LA Detection

Click here to see our ISTH poster, Rahman M, Sadeghi-Khomami A, Black KM. Effect of high-dose direct anticoagulant drugs and DOAC-Remove™ on lupus anticoagulant detection by a hexagonal phase phospholipid assay, 2023. [ISTH Abstract PB1147].

Specimen Management

Coag Conversation Part 3: VWF and ADAMTS13: Cardiovascular Diseases

Introducing The Many Faces of von Willebrand Factor or, von Willebrand Factor, ADAMTS13, Malignancy and Beyond Part 3: von Willebrand Factor and ADAMTS13; Thrombotic Mechanisms and Cardiovascular Diseases. This 30″ talk features George A. Fritsma, MS, MLS, proprietor of The Fritsma Factor, Your Interactive Hemostasis Resource, and Emmanual Favaloro, PhD, Principal Hospital Scientist at the […]

Arterial Thrombosis

CLN: Viscoelastometry Article

Here is a May 2023 Clinical Laboratory News cover review by colleague and fellow “clotter” Oksana Volod, MD, entitled “Is TEG the Right Assay? [click]” The article describes the updated means for near-patient viscoelastometry assays, whose original methodology became available in 1948. Clinical Laboratory News is a widely distributed American Association for Clinical Chemistry [AACC} […]

Global Hemostasis Assays

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

Cheat Sheets from George

Quick Question