Thrombophilia

On-demand HIT Assay

Instrumentation Laboratory announces the July 26, 2016 approval of their HemosIL HIT-Ab(PF4-H) on-demand polyclonal antibody-based latex immunoassay for heparin-induced thrombocytopenia. The assay ifunctions on IL‘s TOP Analyzer series. Attached are IL‘s press release, HIT-Ab(PF4-H) package insert, a 2016 Thrombosis Research article and editorial on the efficacy of on-demand HIT testing. HIT– Ab(PF4-H) Press Release HIT– […]

Weak DRVVT Results

From Tom Exner, Haematek: Hope you had a good 4th of July… Thanks very much for including me sometimes in your interesting online discussions. This time I have an issue on which I would appreciate your advice and possible comments from others if you think it might be suitable for your online interest group. Regarding […]

Undergrad Hemostasis Education

This June 29, 2016 note was posted by Patricia Boyer, MS, MLS, Program Director, Zablocki VAMC School of Medical Technology to the American Society for Clinical Laboratory Science educators bulletin board: I am working on my hemostasis curriculum, and I was wondering how many instructors teach coagulation using the multicomponent complexes–specifically the tenase and prothrombinase complexes concepts. This is my second year […]

Arterial Thrombosis

Lupus Anticoagulant Testing: June 6

On Jun 6, Stago presents a PACE-accredited webinar, Lupus Anticoagulant, Choosing the Right Testing Strategy for Your Laboratory by Dr. Oksana Volod, associate professor of pathology and director of coagulation at Cedars-Sinai Medical Center in Los Angeles, CA. Dr Volod’s presentation is intended to dovetail with the Anti-phospholiipid Sociey’s antiphospholipid syndrome (APS) awareness month. Dr. […]

ADAMTS13 Deficient Plasma

From Bhavna Gaikwad, Sekisui, Inc. Hi, I am in search for TTP disease state plasma, typically ADAMTS-13 deficient plasma (n=20) with the presence of antibodies, for our validation study. I would like to know the commercial suppliers for these clinical samples. Thank you. Hello, Bhavna Galkwad, and thank you for your inquiry. I know of […]

Repeat SRA Testing

From Julia: Hi George, Our physicians order repeat serotonin release assay (SRA) testing on the same patients during the same hospitalization after heparin therapy has been stopped. Sometimes the physicians order within hours. We have called and asked if they are duplicates and they insist they need this testing. Is there research or literature to […]

Anticoagulant Therapy

More on Elevated PC Activity

We’ve had four substantive comments on Kelly Townsend’s January 12, 2016 post about elevated protein C activity, including recent communications from two frequent contributors, Donna Castellone and Dr. Vadim Koustosov. Your comments are also welcome. Geo.

Coagulation Factors

Arterial Thrombosis Profile

From Kelly Townsend, Tricore Laboratories, Albuquerque: We recently had a compliance audit and our consultant suggested that we should offer two separate panels for thrombotic risk; one for arterial and one for venous. Are other labs offering two different hypercoagulable panels? Thank you, Kelly. Participants, when you answer, please list the assays you offer as […]

Mixing Studies and the Rosner Index

Here is another excellent question from Sheila Minor: We use the Rosner index for both interpretation of a PT or PTT mixing study and for LA testing, in which we follow up the DRVVT confirm and ratio with a 50:50 DRVVT mix to resolve discrepancies. Most references state that a Rosner index value of 15 or […]

Lupus Anticoagulant

APCR Controls

From Sheila Minor: We are currently using the Chromogenix Coatest APC Resistance VS kit for APCR testing. Chromogenix provides 1 set of level 1 and level 2 controls in each kit. The instructions state that the controls may be refrozen one time at –20 C or colder in their original vials. That would be fine if we used […]

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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