What is the CHA2DS2-VASc Score?

The CHA2DS2-VASc score assigns points to a series of clinical observations in patients with non-valvular atrial fibrillation (AFIB). CHA2DS2-VASc scores are used to predict the risk of ischemic stroke. The score is computed as follows: Congestive heart failure or left ventricular systolic dysfunction: 1 point Hypertension: BP consistently above 140/90 mmHg or treated hypertension on […]

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Thrombophilia

May 28 2019

george

Quick Question: FVL Order

Our Quick Question for May, 2019 was “A rheumatologist orders a thrombophilia profile that includes a genotypic factor V Leiden mutation assay. You… A. Proceed with the FVL assay: 40% (14) B. First perform the phenotypic APCR: 51% (18) C. Cancel the order: 9% (3) George posted this because the American Society for Clinical Laboratory […]

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Quick Question Archive

May 17 2019

george

Wearable Clot Detector

Nephrologist Vinay Narasimha Krishna, M.D, University of Alabama at Birmingham, developed a wearable clot detection device for which he received one of 15 KidneyX Redesign Dialysis prizes from the U.S. Department of Health and Human Services and the American Society of Nephrology. The device is designed to be worn over the dialysis fistula in real […]

Arterial Thrombosis

Quick Question: Pregnant Woman with DVT

Here is our April, 2019 Quick Question, Adapted from Walenga JM. Chapter 35–Normal Hemostasis. In Keohane EM, Otto CN, Walenga JM. Rodak’s Hematology, Clinical Principles and Applications, 6th Edition, 2020. ISBN 978-0-323-53045-3. A 33-year-old pregnant woman developed deep vein thrombosis in her left leg. She reported a family history—her mother had an episode of superficial […]

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Quick Question Archive

Apr 3 2019

george

Case: DVT During Pregnancy

Our Quick Question case study for April, 2019, is adapted from Chapter 35 of the March, 2019 6th edition of Rodak’s Hematology, Clinical Principles and Applications: A 33-year-old pregnant woman developed deep vein thrombosis in her left leg. She reported a family history–her mother had an episode of superficial thrombophlebitis and her brother had experienced […]

Lupus Anticoagulant

ASH Choosing Wisely Champions

The American Society of Hematology named two Choosing Wisely champions at the 2018 ASH Convention in San Diego. The champions are Prakash Vishnu, MD, of the Mayo Clinic, Jacksonville, who described his work on reducing inappropriate blood. transfusions and Ming Lim, MD, from the Medical University of South Carolina, who described the work that led […]

Bleeding Disorders

2018 ASH VTE Rx Guidelines

As you have noted from our Conference Calendar, the American Society for Hematology annual meeting begins today in San Diego, CA, USA. Foremost in the hemostasis world, ASH today published a series of thoroughly researched and provocative VTE prophylasis and treatment guidelines, which the organization is making available online free of charge. Their offering will […]

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Anticoagulant Therapy

Nov 10 2018

george

REDUCE-IT Trial Results

Today, Saturday, November 10, 2018, Dr. Deepak Bhatt, principal investigator of the Evaluation of the Effect of AMR101 on Cardiovascular Health and Mortality in Hypertriglyceridemic Patients With Cardiovascular Disease or at High Risk for Cardiovascular Disease: REDUCE-IT (Reduction of Cardiovascular Events With EPA – Intervention Trial) reported on encouraging results of the use of high-dose […]

Antiplatelet Therapy

VITAL Trial Results

Click or tap here to learn the results of the VITAL trial conducted by Joann Manson, MD DPH, Beth Israel. The trial looked at the primary endpoints of major cardiovascular disease events and invasive cancer in subjects taking marine omega-3 fatty acids (Omacor® fish oil, (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]], 1 g daily, […]

Antiplatelet Therapy

Quick Question: Normalizing DRVVT Ratio Results

For our October, 2018 Quick Question we asked, “For lupus anticoagulant testing, how do you express the DRVVT screen and confirm results?” Here are the answers from 36 respondents: a. Ratio of screen to confirm: 17 = 47% b. Ratio of screen to confirm normalized to MRI: 17 = 47% c. Difference of screen and […]

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Quick Question Archive

Thrombophilia

What is the CHA2DS2-VASc Score?

Quick Question: FVL Order

Wearable Clot Detector

Quick Question: Pregnant Woman with DVT

Case: DVT During Pregnancy

ASH Choosing Wisely Champions

2018 ASH VTE Rx Guidelines

REDUCE-IT Trial Results

VITAL Trial Results

Quick Question: Normalizing DRVVT Ratio Results

George Fritsma MS MLS

Cheat Sheets from George

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Quick Question