Let’s Use “VITT”

ISTH has chosen the title, Vaccine-induced Immune Thrombotic Thrombocytopenia [VITT] for the adverse event we identified as VAPIT on 4/15/21. ISTH has drafted the attached Interim Guidance for Diagnosis and Treatment of VITT [click]. Watch Fritsma Factor regularly for updates to this document as events unfold.

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Thrombophilia

Apr 15 2021

george

What is VAPIT?

Since the April 14 meeting of the CDC‘s Advisory Committee on Immunization Practices [ACIP, click], information has become available about “Vaccine-Associated Prothrombotic Immune Thrombocytopenia” [VAPIT, or the ultimate name and acronym the scientific community ultimately settles on, if any]. Some vaccine adenovirus vectors may induce a rare autoimmune response that appears to associate with platelet […]

Thrombophilia

LA Interferences

Here is a 2019 poster describing interferences that affect the PTT-based lupus anticoagulant test profile: Effects of Common Interferents in Hexagonal Phase Phospholipid Neutralization Testing by Douglas C, Wood A, Sadeghi-Khomami A, and Black K. The poster features Precision BioLogic’s newly approved CRYOcheck™ Hex LA product.

Thrombophilia

Webinar Recording: VWF: Friend or Foe

A recording of our January 26, 2021 webinar, von Willebrand Factor, Friend or Foe [click] is now available on the BioMedica Diagnotics, Inc. home page. Here is a summary from our January announcements: Von Willebrand factor [VWF] is crucial to platelet adhesion and proper effective coagulation. In addition, VWF appears to be associated with inflammation […]

Events

Jan, 2021 QQ: CFX Answers

Our January, 2021 Quick Question asked, “How does your facility monitor warfarin in an atrial fibrillation [AFIB] patient with lupus anticoagulant [LAC]? The answers were… PT–INR; it is valid in LAC [33%] Chromogenic factor X [10, CFX] [33%] Chromogenic anti-factor Xa [23%] None: we switch to a DOAC [11%] Our question attracted too small a […]

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Anticoagulant Therapy

Jan 11 2021

george

New: CRYOcheck Hex LA

Congratulations to Precision BioLogic Inc. who today announce the release of their newly developed CRYOcheck HexLA® [click]. Following several years in development, CRYOcheck HexLA is FDA cleared, CE Marked, Health Canada authorized and ncluded on the Australian Register of Therapeutic Goods (ARTG). Thanks to PBI’d Elaine Benoit for the heads-up.

Thrombophilia

Jan, 2021 QQ: The Chromogenic Factor X Assay

Before 2010, several articles were published supporting the chromogenic factor X [CFX] assay [not to be confused with the chromogenic anti-factor Xa heparin assay] for monitoring warfarin therapy, especially in patients whose lupus anticoagulant [LAC} could falsely prolong the prothrombin time. Two of these articles are attached below. While the data published made it clear […]

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Anticoagulant Therapy

Dec 21 2020

george

CLS Journal Hemostasis Articles

A recent 2020 Clinical Laboratory Science Journal, publication of the American Society for Clinical Laboratory Science, offers the following hemostasis-related articles, purchasable for $5 each: Nardi MA. Emicizumab and the clinical laboratory. DOI: https://doi.org/10.29074/ascls.119.002204 Ketelson B. Molecular action of ADAMTS13 and transfusion therapies of thrombotic thrombocytopenia pupura. DOI: https://doi.org/10.29074/ascls.120.002287 Ketelson B. An overview of the […]

Bleeding Disorders

DOAC-STOP In Vitro DOAC Removal and LAC

From Asha Rajai: Is it OK to use DOAC-STOP for lupus testing? Has it been approved by ISTH or CLSI? Hello, Asha. Yes, DOAC-STOP [DiaPharma] and DOAC-Remove [Aniara] effectively absorb dabigatran, rivaroxaban, or apixaban from specimens that are submitted for lupus anticoagulant [LAC] testing, allowing for accurate PTT– and DRVVT-based screen and confirm assays for […]

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Anticoagulant Therapy

Nov 3 2020

george

LAC Testing on Warfarin Specimens

A colleatue writes that we frequently encounter cases in which the physician orders a lupus anticoagulant [LC] profile despite a normal PTT. We use Siemens ACTIN FSL and it returns a positive. Of course with a normal PTT, there is no place for mixing study. How to explain this? Also, when taahe patient is on […]

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Thrombophilia

Thrombophilia

Let’s Use “VITT”

What is VAPIT?

LA Interferences

Webinar Recording: VWF: Friend or Foe

Jan, 2021 QQ: CFX Answers

New: CRYOcheck Hex LA

Jan, 2021 QQ: The Chromogenic Factor X Assay

CLS Journal Hemostasis Articles

DOAC-STOP In Vitro DOAC Removal and LAC

LAC Testing on Warfarin Specimens

George Fritsma MS MLS

Cheat Sheets from George

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