Thrombophilia

COVID-19: VWF/ADAMTS13 Balance

Thanks to Brandon Michael Henry MD, Cincinnati Children’s Hospital Medical Center for drawing attention to his award-winning review, co-authored with Drs. Emmanuel Favaloro and Giuseppe Lippi, which details the relationship between von Willebrand factor and ADAMTS13 and applies the VWF/ADAMTS13 activity ratio to the thrombotic progression of the SARS-CoV2 infection. The authors review 67 primary […]

Arterial Thrombosis

Dec 2021 QQ Summary: Thrombosis Risk Profile

Here is the summary of our December 2021 Quick Question, which drew 28 responses. Question: The resident orders a thrombosis risk profile on an inpatient being treated for PE. How do you respond? Run the profile but provide interpretation: 18% [5] Recommend waiting until Rx is D/Ced: 68% [19] Test for lupus anticoagulant only: 4% […]

Quick Question Archive

December 2021 Quick Question: Thrombosis Risk Profile

Our December 2021 question asks, “The resident orders a thrombosis risk profile on an inpatient being treated for a pulmonary embolism [PE]. How do you respond?” This question is inspired by a case study we developed for Rutgers’ CLSC 5124 Advanced Hemostasis fall, 2021 online graduate course. Above is a screen capture that lists several […]

Anticoagulant Therapy

Platelet-Cancer Cell Uptake

Here is an open-access original research report that illustrates cancer cells’ ability to uptake and mimic platelets, leading to access to the platelet proteome, implying that platelets may support metastases: /sites/default/files/plt-ca_cell_uptake_castanheira_jth_2021.pdf

Platelet Function Testing

JTH World Thrombosis Day Virtual Issue

The International Society on Thrombosis and Haemostasis has released a virtual access Journal of Thrombosis and Haemostasis issue devoted to World Thrombosis Day, observed on October 13, 2021. Click here to access the issue, which features a number of open access articles.

World Thrombosis Day 10-13-21

In case you missed it, click here for a review of yesterday’s World Thrombosis Day [WTD] activities and materials. “Venous thromboembolism [VTE] is a condition in which a blood clot forms, most often in the deep veins of the leg, groin or arm [deep vein thrombosis, DVT] and travels in the circulation, lodging in the […]

McMaster Update in Thromboembolism

The McMaster University Continuing Professional Development Office is pleased to present the virtual Seventeenth Annual McMaster Update in Thromboembolism, Friday, October 1, 2021. Thank you to Elaine Benoit, Precision BioLogic, for the heads-up.

Webinar: Rare Thrombotic Response to a SARS-CoV-2 Vaccine

Please join us for a compelling discussion about the rare, unusual thrombotic events that develop in association with thrombocytopenia approximately one to two weeks after vaccination with a SARS-CoV-2 vaccine. This incidence of thrombocytopenia is mediated by platelet-activating antibodies against platelet-factor 4, without any exposure to heparin, and it mimics heparin-induced thrombocytopenia. Don’t miss this […]

Thrombosis in VWF and Hemophilia

From Crystal Wilson: Hello George, I am writing to ask if you could help me to understand how, on rare occasions, patients suffering from bleeding disorders such as von Willebrand disease or hemophilia have suffered from hypercoagulable episodes such as pulmonary emboli or deep vein thrombosis. Thanks. Hello, Crystal, I sent your question to several […]

Bleeding Disorders

July, 2021 Quick Question: Covid Inflammatory Cell Results

Our July, 2021 Quick Question was, “Which cell is the main cause of thrombo-inflammation in a COVID-19 infection?” We had 43 respondents to our selections: Endothelial cell: 35% [15] Platelet: 44% [19] Monocyte-macrophage: 12% [5] polymorphonuclear neutrophil: 9% [4] There’s no right answer, as all of these cells are involved in inflammation, however, many who […]

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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