Jan 26 2026

george

January 2026 QQ Summary: Fibrinolysis

Our January 2026 QQ was a quiz that asked, “What fibrinolytic enzyme digests fibrin?” Here’s how our 34 respondents scored: D-dimer: 0 Plasmin 28 (82%) PAI-1: 2 (6%) TAFI 0 TPA 4 (12%) Congratulations on your successful answers. Here is a summary of fibrinolysis (figure), paraphrased from Walenga JM, Krum KN. Normal Hemostasis. In Keohane EM, […]

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Fibrinolysis

Dec 31 2025

george

January 2026 QQ: Fibrinolysis

Fibrinolysis plays a crucial role in the treatment of thrombosis. The components of fibrinolysis, in no particular order, are plasminogen, plasmin, TPA, TAFI, PAI-1, α2 antiplasmin, FDPs, and D-dimer. Our January 2026 Quick Question in the right column is a quiz that asks, “Which fibrinolysis enzyme digests fibrin?” Please select your answer, and feel free […]

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Fibrinolysis

Dec 30 2025

george

December 2025 QQ Results: Control Proteins

Our December 2025 Quick Question was a quiz that asked, “What plasma control protein acts against FIIa & FXa?” Here’s how our 34 respondents fared… Antithrombin: 27 (79%) Protein C: 5 (15%) Protein S: 1 (3%) Protein Z: 0 TFPI: 1 (3%) We scored well on this question. Antithrombin (AT), when activated by therapeutic heparin […]

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Coagulation Factors

Dec 1 2025

george

November 2025 QQ Summary: Historic Coag Factor Nomenclature

Our November Quick Question summary about Stuart-Prower Factor, linked to a 2023 article by Dave McGlasson about coagulation factor nomenclature. The summary and McGlasson’s article attracted a comment from Dr. Emmanuel Favaloro, which described the nomenclature of traditional and current VWF activity assays.  Dr. Favaloro cited three open-access articles on this topic (click to obtain the […]

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Blog

Nov 28 2025

george

December 2025 Quick Question: Control Proteins

Our December 2025 Quick Question is another quiz, this time about the coagulation control systems. It asks, “What plasma control protein acts against factor IIa (FIIa, thrombin) and factor Xa (FXa, activated FX)? Please answer and add your comment below.

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Quick Question Archive

Nov 28 2025

george

November 2025 QQ Results: Stuart-Prower Factor

Our November 2025 Quick Question asked, “Which is the numeral for the Stuart-Prower factor? Here are the results from our 31 participants: V: 0 (0%0 VII: 3 (10%) X: 19 (61%, correct) XI: 5 (16%) XII: 4 (13%) We scored well. Beginning with the International Committee on Nomenclature’s 1958 recommendations, we began using Roman numerals […]

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Quick Question Archive

Oct 28 2025

george

November 2025 QQ: Stuart-Prower Factor

Our November 2025 Quick Question tests our historical knowledge. Not long ago, we learned about various names for the coagulation factors; e. g., proaccelerin, proconvertin, and plasma thromboplastin antecedent. Some factor names were proper nouns, for example, Hageman factor, Fletcher factor, and Fitzgerald factor. This month’s question asks you to identify the Stuart-Prower factor by […]

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Quick Question Archive

Oct 28 2025

george

October 2025 QQ: Reporting Assay Uncertainty Data Summary

Our October 2025 Quick Question was a poll that asked, “Do you support publishing assay uncertainty data with all results?” The poll attracted 13 respondents who answered: Yes: 4 (31%) No: 8 (62%) It depends: 1 (7%) While the response was small, our question attracted several vigorous comments (click). Generalizing, this hourglass figure, cited in Stroobants […]

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Quick Question Archive

Sep 29 2025

george

October 2025 QQ: Reporting Assay Uncertainty Data

Please refer to our August 29, 2025 discussion, “Hemostasis Assay Statistical Variation.” In this post, we linked the article, Mullier F, Gouin-Thibault I, Meijer P, et al. Time to integrate measurement uncertainty in method comparison and interpretation of hemostasis laboratory assays. Res Practice Thromb Hemost 2025: 9, https://doi.org/10.1016/j.rpth.2025.102993. The authors contend that we should report uncertainty […]

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Quick Question Archive

Sep 29 2025

george

September 2025 QQ: Viscoelastometry Discussion

Our September 2025 Quick Question asked, “What viscoelastometry device is employed at your facility?” A modest group of thirteen participants answered… TEG 6s: 4 (31%) TEG 5000: 2 (15%) ROTEM: 5 (39%) Sonoclot: 0 Hemosonics Quantra: 2 (15%) The TEG 5000 was developed in 1948, and the Sonoclot in 1975; both represent the pioneering phase […]

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Quick Question Archive