Posts

Lupus Anticoagulant Testing and Pooled Normal Plasma

A question about pooled normal plasma for lupus anticoagulant testing from Theo Powers, US Oncology. Hello, George! Great web site, The updated guidelines for lupus anticoagulant (LA) testing refer to making in-house pooled normal plasma (PNP). What are the current recommendations for preparing this pool, such as number of donors, storage, stability? Triplett (Laboratory Evaluation […]

New Quick Question: INR

Please take a moment to answer the quick question posted today, Tuesday, December 15. If you have a question you’d like to see posted as a quick question, please send it to George using the “Ask George” link.

Quick Question Summary: Specimen Hemolysis

Our November Quick Question was “What is your institution’s policy regarding artifactual hemolysis? a. Ignore hemolysis: 4% (3) b. Reject all plasmas with visible hemolysis: 49% (34) c. Assay anyway and append a comment indicating possible interference: 36% (25) d. Assay for plasma hemoglobin and reject plasmas above an established limit: 11% (8) The split […]

Coagulation Cofactors: Why They Aren’t Catalysts

A basic coagulation question from my colleague and co-editor Kathryn Doig, PhD, Michigan State University Clinical Laboratory Science Program: Hi, George. A student and I got into a discussion about the role of factors V and VIII. He contends they are catalysts because they increase the rate of the reactions in which they are involved […]

Meet Dr. Timothy Amukele

On November 4 I had the pleasure of meeting Timothy Amukele, MD, PhD, Fellow in International Clinical Laboratory Medicine and member of the Department of Laboratory Medicine at the University of Washington Medical Center in Seattle. Dr Amukele is affiliated with Pathologists Overseas, a non-government agency formed in 1991 to help improve and provide affordable pathology services […]

HIT Testing: ETI MAX

Dear George, Are you aware of any laboratories that have tried to use the ETI MAX EIA/ELISA system with the GTI PF4 testing products? Thank you, Twyla Bader MT (ASCP) Supervisor/Hematology PeaceHealth Laboratories Bellingham, WA Hi, Twyla, Thank you for your question. No, I am not familiar with that equipment, and have posted this so our participants […]

Why Doesn’t FVIII Deficiency Prolong PT?

A question from Lucas Tarquino at the University of Medicine and Dentistry of New Jersey: Hello, I am a medical student studying for USMLE step 2 and have a question about factor VIII deficiency. Since factors IX and X are in both the intrinsic (partial thromboplastin time, PTT) and extrinsic (prothrombin time, PT) pathways, why […]

New Unfractionated Heparin Formulation

Has anyone in the USA begun using the newly formulated heparin, as described in our October 5 post? If you have, what has been your experience so far? Geo.

Fibrinogen Concentrate

Margaret G. Fritsma, MA (ASCP) SBB came home from the October 2009 American Association of Blood Banks (AABB) annual meeting in New Orleans with information of a new fibrinogen concentrate, RiaSTAP®, available from CSL Behring, King of Prussia, PA. RiaSTAP® has been previously approved for therapy in several Northern European countries. This is a plasma-derived product […]

Von Willebrand Factor Reference Ranges

Some von Willebrand questions from “Charlie” in Edmonton: What are the reference ranges for von Willebrand factor (VWF) antigen and for factor VIII? And what might cause these values to increase in a person who was originally thought to have a problem with being able to clot? Hi, Charlie. the typical reference ranges for VWF […]

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

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