Bovine Chromogenic FVIII Recovery

Click here to read a poster presented at ISLH: Quinton T, Black KM, Sadeghi-Khomami A. Performance of a Novel Bovine Chromogenic Factor VIII Assay in the Recovery of Factor VIII Replacement Therapies. ISLH 2025. The investigators report the efficacy of a chromogenic substrate FVIII assay that employs bovine reagents on several FVIII therapeutics in current use.

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Factor Assays

May 24 2025

george

FVIII-Depleted Reagent Plasma With and Without VWF

The poster, Henneberry S, Rahman M,Wood A, Notini KM, Black KM, Sadeghi-Khomami A. Comparative analysis of commercial factor VIII (FVIII) deficient plasmas with and without von Willebrand factor for FVIII one-stage clotting assay (OSA) was presented on Thursday, 8 May 2025 at the ISLH meeting in Halifax, NS. Click here to see the poster.

Bleeding Disorders

October 2024 Quick Question: Inhibitors

A 9/5/24 question from Chad Siniard, MD, director of the University of Alabama at Birmingham Hospital coagulation service, generated a discussion on the FVIII level that a facility chooses to generate an order for a Nijmegen-Bethesda FVIII inhibitor assay. Our October 2024 Quick Question (on the right) is a poll that asks, “At what FVIII […]

Bleeding Disorders

June 2024 QQ Poll Summary: OSA and Chromogenics

Our June 2024 Quick Question attracted 18 responses. This month’s Question was a poll that asked, “How do you assay factor concentrates?” Here are our answers: Clot-based assay: 11 [61%] Chromogenic substrate assay: 4 [22%] Other: 3 [17%] Factor assays are most often requested to monitor hemophilia factor concentrate activity for patient-specific efficacy and the […]

Factor Assays

Lab Assays to Detect Occult Cancer in VTE

Here is a provocative article whose investigators looked for lab assays to detect cancer in patients with unprovoked venous thromboembolism: Sánchez-López V, Marín-Romero S, Ferrer-Galván M, et all. Occult cancer in patients with unprovoked venous thromboembolism: A nested case-control study. Am J Clin Pathol. 2024:aqad178. doi: 10.1093/ajcp/aqad178. Epub ahead of print. PMID: 38340336.

Factor Assays

Interpreting Inhibitor Mixing Study in a Hemophilia A Patient

I [Geo] received a physician’s question on 1-31-24: Dear Sir, Hope you are doing well. Thank you for creating this platform and sharing valuable resources with the world. We present a case of Hemophilia A with recent retroperitoneal hematoma and multiple transfusions–PRBC, FFP, Factor VIII, and NovoSeven. APTT of Test Plasma: 47 seconds [RI 22.2–33.1 […]

Mixing Studies

October 2023 Quick Question: Should we Update Coag Factor Names?

Our October 2023 Quick Question follows up a provocative discussion that started with a question by Dave McGlasson who had seen recent hemostasis publications that used Arabic numerals [alternatively called Western or European numerals] instead of Roman numerals. For clarity, Mr. McGlasson was not referring to genetic terminology, which has always used, for example, F8 […]

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Quick Question Archive

Nov 15 2022

george

Poster: a Handheld Fibrinogen Assay Device

The qLab FIB is a recently introduced handheld point-of-care device that returns a fibrinogen result within ten minutes using a single drop of citrated whole blood.

Factor Assays

Factor XIII Control?

From “Kaarin,” We are wondering what other labs are using for a positive (deficient) control for factor XIII assay by the clot-lysis methodology. Deficient plasma? Hello, Kaarin, thanks for your question, which will attract some responses soon. A quick check of major plasma control distributors shows that only Hyphen BioMed, distributed in North America by Aniara, […]

Blog

Chromogenic Factor IX Assay Validation

Click below for a poster that was presented at the Thrombosis and Hemostasis Summit of North America [THSNA], August 16–18, 2022 that features a recently released chromogenic factor IX assay: Quinton T, Fraser J, Black KM, Sadeghi-Khomami A. Validation of a new kit for the determination of factor IX activity, Poster 418, Precision BioLogic Inc., […]

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Bleeding Disorders

Factor Assays

Bovine Chromogenic FVIII Recovery

FVIII-Depleted Reagent Plasma With and Without VWF

October 2024 Quick Question: Inhibitors

June 2024 QQ Poll Summary: OSA and Chromogenics

Lab Assays to Detect Occult Cancer in VTE

Interpreting Inhibitor Mixing Study in a Hemophilia A Patient

October 2023 Quick Question: Should we Update Coag Factor Names?

Poster: a Handheld Fibrinogen Assay Device

Factor XIII Control?

Chromogenic Factor IX Assay Validation

George Fritsma MS MLS

Cheat Sheets from George

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