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April 2023 Quick Question: Prince Alexis

On 3/30/2023 we posted a series of three updated hemophilia audio PowerPoints. Our April 2023 Quick Question asks “What was Russian Prince Alexis’s disorder?” The choices are: Hemophilia A [FVIII deficiency] Hemophilia B [FIX deficiency] Hemophilia C [FXI deficiency] Unknown. You will find the answer under Educational Modules, Hemophilia Part 1: History

Mixed DOACs and the DOAC Clotting Time Test

In a January 2023 letter to the editor, available from the publisher or your library as Exner T, Ellwood L, Dangol M, Favaloro EJ. Mixing factor Xa and thrombin inhibiting direct oral anticoagulants produces a synergistic prolonging effect on most clotting tests. Int J Lab Hematol. 2023 Feb 21. doi: 10.1111/ijlh.14043, investigators examined a DRVVT-based […]

Anticoagulant Therapy

Precision BioLogic Chromogenic FIX Assay Cleared by the FDA

Congratulations to our sponsor, Precision BioLogic Inc., as their CRYOcheck chromogenic factor IX assay was cleared by the US Food and Drug Administration on January 5, 2023. Click here for PBI’s news release. and click “Factor IX Testing and Introduction to CRYOcheck Chromogenic Factor IX” to register for our February 1 webinar featuring special guest […]

Coagulation Factors

The Dilute Thrombin Time Measures DTIs

Here is the abstract of a pre-publication release comparing direct thrombin inhibitor results from the plasma-diluted thrombin time [DTT] to the partial thromboplastin time [PTT]:

Anticoagulant Therapy

November, 2022 Quick Question

Please visit and respond to our November 2022 Quick Question, submitted by Dave McGlasson. The question asks, "If you use the PT when no warfarin is being measured, how do you

Choosing Wisely Recommendations 11-7-22

Ten new Choosing Wisely recommendations [tap or click] were released Monday, November 7, 2022.

New Antiplatelet Drug in Phase 2

This message remained in draft form in our prior Fritsma Factor site, which was discontinued yesterday, Tuesday, November 1.

Fritsma Factor Gets New Skin

Fritsma Factor participants, you've arrived at our newly remodeled FF home page.

October 2022 Quick Question Summary: Underfilled Tubes

A September 20 inquiry from Carolina Vilchez inspired our October Quick Question. Here are the stem and responses from 35 participants:

Factor XIII Control?

From “Kaarin,” We are wondering what other labs are using for a positive (deficient) control for factor XIII assay by the clot-lysis methodology. Deficient plasma? Hello, Kaarin, thanks for your question, which will attract some responses soon. A quick check of major plasma control distributors shows that only Hyphen BioMed, distributed in North America by Aniara, […]

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

Cheat Sheets from George

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