Bleeding Disorders

May 2024: QQ Poll: Trigger Point for PLT Concentrate Therapy

Our May 2024 Quick Question asks, “Below what PLT count limit do you provide PLT concentrate?” Please show us your facility’s PLT count limit and add a comment below or using the Questions or Comments box.

Bleeding Disorders

April 2024 QQ Summary: MYH9 Mutation

Our April 2024 Quick Question, “What PLT production abnormality is an MYH9 gene mutation?” attracted 26 responses. Here’s the distribution: Thrombocytopenia with absent radii [TAR]: 4 [15%] Bernard-Soulier syndrome [BSS]: 2 [7%] Immune thrombocytopenia [ITP]: 1 [4%] Wiskott-Aldrich syndrome: 1 [4%] May-Hegglin disorder: 18 [70%] The production abnormalities are associated with mild to severe bleeding. […]

Bleeding Disorders

VWD Diagnosis and Monitoring Update

Dr. Annette Bowyer posted this open-access publication today, 3-3-24 on LinkedIn: Platton S, Baker P, Bowyer A, et al. Guideline for laboratory diagnosis and monitoring of von Willebrand disease: A joint guideline from the United Kingdom Haemophilia Centre Doctors’ Organisation and the British Society for Haematology. Br J Haematol. 2024 Mar 26. doi: 10.1111/bjh.19385. Epub […]

Bleeding Disorders

April 2024 QQ: MYH9 Mutation

Molecular diagnostic methods have defined scores of platelet disorders that by phenotype alone were categorized as production or functional disorders. Our April 2024 Quick Question is a quiz that “scratches the surface” by asking what disorder or syndrome is part of the MYH9 gene mutation family. For a look at molecular diagnostics practical applications, see […]

Platelet Function Testing

March 2024 Quick Question Summary: Factor Deficiency

Our March 2024 Quick Question was a quiz. The question was, “What factor deficiency causes bleeding but doesn’t prolong the PT or PTT?” Our 75 respondents answered as follows: FVIII: 7 [9%] FIX: 3 [4%] FXI: 3 [4%] FXII: 8 [11%] FXIII: 54 [72%] Factor VIII, IX, XI, and XII deficiencies prolong the PTT but […]

Bleeding Disorders

How to Measure Plasma Efanesoctocog Alfa [Altuviiio]

For those like me (Geo) who are just learning of it, efanesoctocog alfa (Altuviiio™), US FDA-approved in February of 2023 is Sanofi/Sodi’s extended half-life synthetic FVIII concentrate. Here is an edited description of Altuviiio’s structure and PK from the package insert. Altuviiio (efanesoctocog alfa, ehtl, recombinant AHF, Fc–VWF-XTEN fusion protein) replaces missing FVIII needed for […]

Bleeding Disorders

March 2024 Quick Question: Factor Deficiency

Our March 2024 Quick Question, a factor deficiency quiz asks “What factor deficiency causes bleeding but doesn’t prolong the PT or PTT?” Please select the one correct answer and make additional comments below.

Bleeding Disorders

February 2024 QQ Summary: Rosenthal Syndrome

Forty-two participants answered our February 2024 Quick Question, “What factor deficiency is named Rosenthal syndrome?” Here are the answers: FV: 3 [7%] FVII: 2 [5%] FX: 2 [5%] FXI: 28 [67%] FXII: 5 [11%] FXIII: 2 [5%] Most of us correctly chose factor XI deficiency, Rosenthal Syndrome. FXI deficiency is an autosomal recessive hemophilia with […]

Bleeding Disorders

History of TTP

Thanks to Dr. X. Long Zheng, Professor and Chair of Pathology and Laboratory Medicine, University of Kansas, for his LinkedIn reference to this 2017 open access thrombotic thrombocytopenic purpura history: Saha M, McDaniel JK, Zheng XL. Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics. J Thromb Haemost. 2017 Oct;15(10):1889-1900. doi: 10.1111/jth.13764.

Arterial Thrombosis

Mixing Studies and the Rosner Index

Here is a 2-12-2024 message from Brenda Goforth, Senior CLS Hematology, Coagulation, and Urinalysis; Clinical Laboratory Antelope Valley Medical Center, Lancaster, CA 93534. Hello, I would like some clarification on the subject of mixing studies using the Rosner Index cutoff compared to the “>10% of the normal pooled plasma [NPP] limit” in regards to incubation […]

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

Cheat Sheets from George

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