Bleeding Disorders

QQ Results: 5 YO Girl with Systemic Bleeding

Our January, 2020 Quick Question was based on our December 26, 2019 case, 5 YO Girl with Systemic Bleeding. This case generated discussion from experts around the world, whose comments are provided below. But first, here is the question and responses. Question: What diagnosis fits no aggregation reponse to ADP, collagen, and AA? The question […]

Bleeding Disorders

New Chromogenic Factor VIII Assay

In a January 20, 2020 press release, Fritsma Factor sponsor Precision BioLogic Inc. announced the availability of its new CRYOcheck Chromogenic Factor VIII assay in Canada, the European Union, Australia, and New Zealand following market authorization by Health Canada and the respective in-country regulatory authorities. This assay offers a test range from 0–200% FVIII using […]

Bleeding Disorders

QQ: 5 YO Girl with Systemic Bleeding

On February 24, 2011, George responded privately to a question posted to the American Society for Clinical Laboratory Science Consumer Web Forum from the parent of a 5-YO girl. The girl had experienced epistaxis and easy bruising from birth. Platelet aggregometry, performed on a specimen taken January 23, 2007 (1 YO) reported no aggregation to […]

Bleeding Disorders

Quick Question: PT substitute

Our November, 2019 Quick Question asks, “What may you substitute for the PT when LAC prolongs the PT?” This question addresses the unreliability of the PT for monitoring Coumadin therapy when lupus anticoagulant interferes by prolonging the result. It is also relevant to PT prolongation by fibrinogen deficiency or factors II, V, VII, or X […]

Anticoagulant Therapy

Quick Question: Liver Disease or VK Deficiency?

Here are the results to our October, 2019 Quick Question, “What factor assays do you perform to distinguish liver disease from vitamin K deficiency?” a. II and V: 13 (15%) b. V and X: 10 (12%) c. II and X: 8 (9%) d. V and VII: 44 (51%) e. VII and X: 11 (13%) The […]

Bleeding Disorders

Factor VIII and XIII Deficiency?

I responded to a recent inquiry on the subject of a possible combined factor VIII and XIII deficiency. The comment is appended to a December 28, 2010 discussion of this possibility, which seems vanishingly rare. I’d like to hear from our participants if they’ve had any recent experience suggesting a combined deficiency>

Bleeding Disorders

October 2019 QQ: Distinguish Liver Disease from VK Deficiency

Our October, 2019 is a poll designed to learn how your coagulation laboratory distinguishes hemorrhage caused by liver disease from hemorrhage caused by vitamin K deficiency. If you have an alternative not provided among the possible answers, please post your comment here.

Bleeding Disorders

September, 2019 QQ Response: Poor Wound Healing

Here is our September, 2019 Quick Question with responses from 100 participants. A 25-YO experienced chronic soft tissue bleeding and poor wound healing. His PT, PTT, and PLT count were normal. What follow-up assay is indicated? a. Platelet aggregometry 24 (24%) b. Factor VIII and IX assay 12 (12%) c. Factor XIII assay 37 (37%) […]

Bleeding Disorders

New Statistics on Hemophilia Prevalence

Thanks to Elaine Benoit, Precision BioLogic Inc., for the heads-up on this newly released hemophilia study revealing a higher prevalence than previously reported. Also, the life expectancy disadvantage data are striking. Researchers from McMaster University, North Carolina State University, Aix-Marseille University, and the University of Sheffield joined efforts to respond to a call to action […]

Bleeding Disorders

A Link Between aHUS and TTP

Click or tap September 3, 2019 UAB News for an article featuring X. Long Zheng, MD, PhD, Robert B. Adams Professor of Pathology and Division Director of Laboratory Medicine at the University of Alabama at Birmingham. Using knockout mice, Dr. Zheng’s group has established a link between complement control protein H deficiency, a mechanism that […]

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

Cheat Sheets from George

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