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A Link Between aHUS and TTP

Click or tap September 3, 2019 UAB News for an article featuring X. Long Zheng, MD, PhD, Robert B. Adams Professor of Pathology and Division Director of Laboratory Medicine at the University of Alabama at Birmingham. Using knockout mice, Dr. Zheng’s group has established a link between complement control protein H deficiency, a mechanism that leads to atypical hemolytic-uremic syndrome (aHUS) and ADAMTS13 deficiency, the cause of recurrent thrombotic thrombocytopenic purpura. The link cites a pre-pub: Zheng L, Zhang D, Can W, Song WC, Zheng XL. Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy. Blood 2019, which will appear in print later this year.

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