February 2024 QQ Summary: Rosenthal Syndrome

Forty-two participants answered our February 2024 Quick Question, “What factor deficiency is named Rosenthal syndrome?” Here are the answers: FV: 3 [7%] FVII: 2 [5%] FX: 2 [5%] FXI: 28 [67%] FXII: 5 [11%] FXIII: 2 [5%] Most of us correctly chose factor XI deficiency, Rosenthal Syndrome. FXI deficiency is an autosomal recessive hemophilia with […]

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Bleeding Disorders

Feb 26 2024

george

History of TTP

Thanks to Dr. X. Long Zheng, Professor and Chair of Pathology and Laboratory Medicine, University of Kansas, for his LinkedIn reference to this 2017 open access thrombotic thrombocytopenic purpura history: Saha M, McDaniel JK, Zheng XL. Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics. J Thromb Haemost. 2017 Oct;15(10):1889-1900. doi: 10.1111/jth.13764.

Arterial Thrombosis

Mixing Studies and the Rosner Index

Here is a 2-12-2024 message from Brenda Goforth, Senior CLS Hematology, Coagulation, and Urinalysis; Clinical Laboratory Antelope Valley Medical Center, Lancaster, CA 93534. Hello, I would like some clarification on the subject of mixing studies using the Rosner Index cutoff compared to the “>10% of the normal pooled plasma [NPP] limit” in regards to incubation […]

Mixing Studies

Interpreting Inhibitor Mixing Study in a Hemophilia A Patient

I [Geo] received a physician’s question on 1-31-24: Dear Sir, Hope you are doing well. Thank you for creating this platform and sharing valuable resources with the world. We present a case of Hemophilia A with recent retroperitoneal hematoma and multiple transfusions–PRBC, FFP, Factor VIII, and NovoSeven. APTT of Test Plasma: 47 seconds [RI 22.2–33.1 […]

Mixing Studies

Please Provide Comments: Prolonged PT and PTT, Retinal Bleed

I’m [Geo] seeking comments about this case of a 65-YOA female on no anticoagulant with retinal hemorrhage and no other bleeding symptoms: Coag 1/18/24 1/19/24 1/20/24 1/21/24 PT 16.9 15.6 PTT 53 44 TCT 17 FG 592 576 FII 83 FV 79 FVIII 167 FIX 71 FX 75 FXI 80 VWF:Ag 121 VWF:RCo 147 D-dimer […]

Bleeding Disorders

WFH Statement on Cryoprecipitate

The World Federation of Hemophilia [WFH] is deeply concerned by the inclusion of pathogen-reduced and non-pathogen-reduced cryoprecipitate in the World Health Organization’s 23rd Essential Medicines List [EML] and Essential Medicines List for Children [EMLC]. Click here for the 12-23-23 WFH statement.

Bleeding Disorders

January 2024 Quick Question: Platelet Function Tests

Our January 2024 question is a poll submitted by Dave McGlasson, asking, “What platelet function test do you use?” While light transmittance aggregometry [LTA] has been available since the mid-1960s and is regarded by many as the reference method for platelet function testing, many have switched to the simpler whole blood aggregometry [WBA]. Our answers […]

Bleeding Disorders

December 2023 Quick Question Summary: VWD Subtype 2B

Our December 2024 Quick Question, “How do you test for VWD subtype 2B?” attracted 31 responses as follows: RIPA: 15 [48%] VWFAg: 2 [7%] VWF:CB: 5 [16%] VWF:RCo: 6 [19%] Multimeric analysis: 3 [10%] Our question drew this comprehensive discussion from Dr. Emmanuel Favaloro on Tuesday, December 12, 2023: Hi George, I have been following […]

Bleeding Disorders

FVII Deficiency

I [Geo] received this post on Monday, December 18: Hi George, I have a few questions that I was hoping you could help me with. I’m a patient with factor 7 deficiency and have a background in nursing. I was diagnosed at 49% but have had issues with fluctuations in percentages between standalone labs and […]

Bleeding Disorders

Acquired Hemophilia, rpVIII, and Bethesda Titer

Here is a 12-2-23 email from Hrvoje Melinšćak MD, Consultant in Haematology, the Warren Alpert Medical School of Brown University, Rhode Island Hospital/The Miriam Hospital. I would enquire regarding rpFVIII’s impact on inhibitor titre assessment through the Bethesda assay in a case regarding acquired haemophilia A. Does significant background rpFVIII (Obizur) concentrate lend to significant […]

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Bleeding Disorders

Bleeding Disorders

February 2024 QQ Summary: Rosenthal Syndrome

History of TTP

Mixing Studies and the Rosner Index

Interpreting Inhibitor Mixing Study in a Hemophilia A Patient

Please Provide Comments: Prolonged PT and PTT, Retinal Bleed

WFH Statement on Cryoprecipitate

January 2024 Quick Question: Platelet Function Tests

December 2023 Quick Question Summary: VWD Subtype 2B

FVII Deficiency

Acquired Hemophilia, rpVIII, and Bethesda Titer

George Fritsma MS MLS

Cheat Sheets from George

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