Arterial Thrombosis

What is PITT?

Click below for an open-access article that classifies VITT and HIT as members of a platelet factor 4 (PF4) disorder, anti-PF4 mediated thrombocytopenia and thrombosis (PITT). Nicolson PLR, Montague SJ, Buka RJ, et al. Anti-PF4 mediated thrombocytopenia and thrombosis associated with acute cytomegalovirus infection displays both HIT-like and VITT-like characteristics. Br J Haematol. 2025. doi: […]

Arterial Thrombosis

History of TTP

Thanks to Dr. X. Long Zheng, Professor and Chair of Pathology and Laboratory Medicine, University of Kansas, for his LinkedIn reference to this 2017 open access thrombotic thrombocytopenic purpura history: Saha M, McDaniel JK, Zheng XL. Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics. J Thromb Haemost. 2017 Oct;15(10):1889-1900. doi: 10.1111/jth.13764.

Arterial Thrombosis

VWF in Malignancy

In the Rutgers CLSC 5124 Advanced Hemostasis graduate course, a participant responded to the question, “What do both Dr. Favaloro and Dr. Henry indicate about the role of platelets in metastatic carcinoma?.” The question referred to our Coag Conversations with Dr. Emmanuel Favaloro, The Many Faces of VWF. and with Dr. Brandon Henry, What Have […]

Arterial Thrombosis

VWF in Cardiac Disorders

In the Rutgers CLSD 5124 Advanced Hemostasis graduate course, a participant responded to the question, “Show how VWF and platelets appear to be involved in cardiac insufficiency and atrial fibrillation.” The question referred to our Coag Conversation with Dr. Emmanuel Favaloro, The Many Faces of VWF. The response: VWF is a glycoprotein heavily engaged in […]

Arterial Thrombosis

Trauma-induced Coagulopathy Conversation Part 3

Part 3 of my Coag Conversation with Dr. Maureane Hoffman entitled Trauma-induced Coagulopathy; The Laboratory’s Role in Care, is now available from the BioMedica Diagnostics website.

Bleeding Disorders

FXII and Inflammation

This question was posted in the Rutgers graduate course, CLSC 5124 Advanced Hemostasis: Explain how FXII and FXI are activated by vascular assist devices and show their connection with inflammation. Here is an answer provided by one of the course participants: The contact pathway may be initiated by FXII binding to a negatively charged surface […]

Arterial Thrombosis

November 2023 Quick Question: Platelet Hyperaggregability Summary

Our modest 15-player response to the November 2023 Quick Question poll implies a scant interest in platelet hyperaggregability, the outcome of an October 4 post by Mayukh Sarkar, PhD. “Sticky Platelet Syndrome.” Question: Do you test for platelet hyperaggregation? No, there’s no such thing: 6 [40%] Yes, we call it “sticky platelets:” 6 [40%] We […]

Arterial Thrombosis

Coag Conversation Part 3: VWF and ADAMTS13: Cardiovascular Diseases

Introducing The Many Faces of von Willebrand Factor or, von Willebrand Factor, ADAMTS13, Malignancy and Beyond Part 3: von Willebrand Factor and ADAMTS13; Thrombotic Mechanisms and Cardiovascular Diseases. This 30″ talk features George A. Fritsma, MS, MLS, proprietor of The Fritsma Factor, Your Interactive Hemostasis Resource, and Emmanual Favaloro, PhD, Principal Hospital Scientist at the […]

Arterial Thrombosis

Webinar: The Many Faces of VWF, Part 2: Tumor Progression

Fritsma Factor participants, we invite you to view the next installment of our video series “Coag Conversations:” Dr. E. J. Favaloro: The Many Faces of von Willebrand Factor; or Von Willebrand Factor, ADAMTS13, Malignancy, and Beyond Part 2: Von Willebrand Factor and ADAMTS13: Tumor Progression and Beyond, sponsored by BioMedica Diagnostics, Inc.

Thrombotic Microangiopathies Presentation Handout

Click for the handout for “von Willebrand Factor, Friend or Foe,” which George presented on Friday, April 21, and Friday, April 29, 2023.

Arterial Thrombosis

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

Cheat Sheets from George

Quick Question