Anticoagulant Therapy

Algorithm for DOAC Dipstick Application

Click here for the open-access article: Harenberg J, Gosselin RC, Cuker A, et al. Algorithm for rapid exclusion of clinically relevant plasma levels of direct oral anticoagulants in patients using the DOAC dipstick: an expert consensus paper. Thromb Haemost. 2024;124:770–7. doi: 10.1055/a-2261-1811. PMID: 38316416. Abstract Background With the widespread use of direct oral anticoagulants (DOACs), there […]

Anticoagulant Therapy

Anticoagulation Therapy Review

Dr. Emmanuel Favaloro’s 2018 open access review article “Anticoagulation therapy in Australia” has received 10,000+ views! The article is available for free download at: https://lnkd.in/gfcsyW5s. If you prefer the updated version published in JCM in 2025, during and post COVID-19, then head to https://lnkd.in/gAnPWn_E for a free download.

Anticoagulant Therapy

Reprise: In Vitro DOAC Removal

At the request of the Annals of Blood editor, here is a link to our 2020 article on in vitro DOAC removal agents, which has attracted >5000 page views: McGlasson DL Fritsma GA. In vitro detection and removal of direct oral anticoagulants from patient plasma specimens. Ann Blood 2020;5:25 | http://dx.doi.org/10.21037/aob-20-16. The article was first […]

Anticoagulant Therapy

Elevated PT/INR Case

This question recently appeared in the Diagnostic Health Equity site, managed by Tamara Lobban-Jones. “My doctor said my PT/INR was a little high. What does that actually mean for me, and should I be worried about bleeding more easily? I’ve been on a blood thinner for a while, but my PTT keeps coming back different […]

Anticoagulant Therapy

A Review of Current and Developing DOAC Reversal Agents

Check with your medical library for this comprehensive review of current and developing DOAC reversal agents: Gómez-Outes A, Suárez-Gea ML, Lecumberri R. When and how to use reversal agents for direct oral anticoagulants? Curr Cardiol Rep. 2023;25:371–80. doi: 10.1007/s11886-023-01858-x. PMID: 36976497. Abstract Purpose of review: Our objective is to describe currently available reversal agents for […]

Anticoagulant Therapy

Heparin Resistance in Pancreatitis

Click this open-access article to read about heparin resistance in an acute pancreatitis patient with a normal antithrombin level: Rongqin D, Zhexin B, Yuzhi L, et al. Heparin resistance in a patient with severe acute pancreatitis: a case report. Lab Med. 2025;56:570–6. doi: 10.1093/labmed/lmae126. PMID: 40237706; PMCID: PMC12417076. Here’s the abstract: Introduction: Severe acute pancreatitis […]

Anticoagulant Therapy

ESC: Extended Apixaban Rx

Click here for an ESC news release: Extended apixaban therapy lowers recurrent VTE in patients with provoked events and enduring risk factors, released 9-1-2025.

Anticoagulant Therapy

Post-Orthopedic Surgery Anticoagulation

Click here to receive the open-access review article, Sarkar MK, Laposata M. Is aspirin the best choice today for prophylaxis against venous thromboembolism after orthopedic surgery? Tex Ortho J 2017:3; 45–54 DOI: 10.18600/toj.030407. Sarkar and Laposata reviewed various agency guidelines for all AC therapy over the past several years and provided the current recommendations.

Anticoagulant Therapy

August 2025 QQ: Direct Oral Anticoagulants

Our August 2025 QQ is a poll that asked, “What AC does your provider prescribe for non-valvular AFIB?” Here are the choices made by our 18 responders: Apixaban (Eliquis) 10 (56%) Clopidogrel (Plavix) 0 Dabigatran (Pradaxa) 3 (16%) Rivaroxaban (Xarelto) 1 (6%) Warfarin (Coumadin) 4 (22%) This QQ arose from discussions with my (Geo) PCP […]

Anticoagulant Therapy

Charcoal Adsorbents Remove Anti-FXIa Interference

My (Geo) audio PowerPoint, Managing Direct Oral Anticoagulants, was posted in 2021. One of the final slides indicates experimental anticoagulant formulations designed to suppress FXI activation, aiming to reduce thrombotic risk without increasing the risk of bleeding. Click open-access article Buckley GT, Crowley MP, Harte JV. Interferences associated with the factor XIa inhibitors asundexian and […]

Anticoagulant Therapy

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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